Objective
"Intelligent behavior depends on the ability to generate flexible, context-dependent actions. In the brain it is known that sensory cortices receive the top-down signal from higher cortical areas, which provides ""executive control"" and specifies the context or rules currently in effect. However, little is known about how this top-down signal is integrated by neurons and eventually influences the behavior of animals. Of special importance for this integration are the distal apical dendrites of cortical pyramidal neurons because top-down fibers target layer 1 of the cortex which are densely innervated by these structures. Furthermore, pyramidal neurons have specialized molecular machinery in just this region of the cell that dominate the integrative process and dictate firing output. We therefore hypothesize that optically manipulating the dendritic activity should influence the behavior of awake animals. We will test this hypothesis by measuring how the dendritic activity is modulated by the animal's behavior (Aim 1) and how active manipulation of dendritic activity influences the behavior (Aim 2). Specifically, we will image and optogenetically manipulate the calcium activity of the apical tuft dendrite of layer 5 pyramidal neurons by targeting light activatable proteins to the dendrites. While animals perform a context-dependent task, e.g. licking or withholding licking based on the context in which a tactile stimulus is given to their limbs, we will compare the effects of light-based activation and inactivation of the dendrites. The host laboratory has recently developed the fiberoptic periscope system that has huge potential to reveal the contribution of a specific dendritic region to the large network activity. Through combined use of fiberoptic system, optogenetic technique and well-characterized behavior, we hope to provide important new insight into the cellular mechanism of the cognitive/sensorimotor interface underlying flexible behavior."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology materials engineering fibers
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
10117 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.