Objectif Targeted therapy remains one of the greatest challenges in modern medicine. In response, I propose synthetic, liposomal vectors capable of delivering diverse and clinically relevant therapies to targeted sites in the body, whose therapeutic action is triggered exclusively by applied light. This approach challenges traditional approaches to targeted vector-based therapies and addresses the common failings of existing technologies. The use of light as a stimulus for therapy makes this technology ideally suited to the treatment of skin disorders, including melanoma and non-melanoma skin cancers, dominant negative genetic disorders, infection and inflammation.In execution, the interdisciplinary research program will be a logical and through progression from organic chemistry to cell culture lab and will be underpinned by foreseen pan-European collaboration. The 2-year program will validate the proposed vector as a viable technology for future animal studies and I expect to be in a strong position to apply for follow-up funding following the Fellowship.My 5-year career goal is to establish my own independent research group at one of Europe’s top university backed by long-term and prestigious funding. To achieve this, I must be able to demonstrate: 1) Practical experience across a wide range of disciplines spanning chemistry and biology, 2) Project leadership, 3) People management and mentoring skills, 4) Exposure to and experience of the relationship between academic and commercial sectors, 5) A strong track record of publication and grant applications, 6) Presentation skills, and 7) Demonstrated track record of working effectively in cross-discipline and international collaborations. This proposal has been carefully designed to provide me with all these attributes, putting me in the strongest possible position to achieve my future career ambitions. Champ scientifique natural scienceschemical sciencesorganic chemistrymedical and health sciencesclinical medicineoncologyskin cancermelanoma Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2012-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur UNIVERSITEIT LEIDEN Contribution de l’UE € 175 974,60 Adresse RAPENBURG 70 2311 EZ Leiden Pays-Bas Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Type d’activité Higher or Secondary Education Establishments Contact administratif Tonnis Brouwer (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
