Objetivo Sclerotinia sclerotiorum is a necrotrophic fungus notorious for its broad host range, including notably oilseed rape, sunflower, lettuce, carrot, onion and potato. In most cases there is no variety with significant resistance or tolerance known to date. Small secreted proteins and low molecular weight metabolites have been reported in several necrotrophic fungi as critical for virulence. However, the role of these effector proteins in S. sclerotiorum virulence is largely unknown, and the molecular mechanisms by which S. sclerotiorum promotes host susceptibility remain poorly understood. We recently discovered that susceptibility to S. sclerotiorum is highly variable among A. thaliana accessions and our preliminary analyses on S. sclerotiorum genome sequence identified promising effector candidates. The objective of this proposal is to validate the function of S. sclerotiorum effector candidates in altering plant cells to promote susceptibility. We will (i) document the diversity of S. sclerotiorum effector protein candidates; (ii) identify effector candidates that promote susceptibility to S. sclerotiorum and (iii) identify effector candidates required for S. sclerotiorum virulence. This project will have a significant impact on our understanding of plant-microbe interactions by providing insights into key molecular processes regulating susceptibility to a necrotrophic pathogen. Besides, it will open new perspectives toward the development of tolerant crop varieties. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesmicrobiologymycologyagricultural sciencesagriculture, forestry, and fisheriesagriculturegrains and oilseedsoilseedsnatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Convocatoria de propuestas FP7-PEOPLE-2012-CIG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-CIG - Support for training and career development of researcher (CIG) Coordinador INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT Aportación de la UE € 100 000,00 Dirección 147 RUE DE L'UNIVERSITE 75007 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Sandrine Barrère (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
