Objectif "How can we construct a high-resolution camera capable of imaging the time-of-arrival, polarisation and wavelength of each of the maximal 10Gphoton/s emitted from a labelled, biological cell?Such a measurement would capture the complete information available in the optical signal, and significantly enhance our ability to observe the organisation, movement and interactions of cellular components at molecular scales. Advances in single molecule light microscopy are steadily improving our understanding of the processes underlying normal cellular function, and their alteration in disease states. However, these technologies are unable to reach their full potential due to their reliance on pre-existing, suboptimal detectors. A dedicated camera technology is now required to permit simultaneous, multidimensional measurements of large cohorts of molecules at high temporal and spatial (sub-diffraction limit) scales through total imaging of the photon flux.Today’s digital cameras capture photons in packets of 10-100 thousand and provide them for external display or recording at fraction of second intervals. In order to process photons individually rather than as packets we must develop a camera operating 10-100 thousand times faster. Each pixel must be capable of capturing single photon parameters without compromising the high resolution and sensitivity achieved by current technology. The ""total photon"" camera will be realised in nanoscale CMOS technology, based on recent breakthroughs in ultra-miniature single-photon detectors. We will combine these with novel approaches to pixel circuits, image processing and high-speed readout electronics to provide a fundamental research tool for the emerging area of computational microscopy. We will provide access to the full record of photon emission from live cells, and hence the clearest possible visualization of dynamic cellular processes in a single device capable of wide-field molecular spectroscopy and superresolution imaging." Champ scientifique engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsoptical sensorsnatural sciencesphysical sciencesopticsmicroscopysuper resolution microscopynatural sciencesphysical sciencestheoretical physicsparticle physicsphotonsnatural sciencesphysical sciencesopticsspectroscopy Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-PE7 - ERC Advanced Grant - Systems and communication engineering Appel à propositions ERC-2013-ADG Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil THE UNIVERSITY OF EDINBURGH Contribution de l’UE € 1 354 862,00 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Royaume-Uni Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Alan Kennedy (Mr.) Chercheur principal Robert Kerr Henderson (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (2) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire THE UNIVERSITY OF EDINBURGH Royaume-Uni Contribution de l’UE € 1 354 862,00 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Alan Kennedy (Mr.) Chercheur principal Robert Kerr Henderson (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée HERIOT-WATT UNIVERSITY Royaume-Uni Contribution de l’UE € 925 370,00 Adresse Riccarton EH14 4AS Edinburgh Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Eva Olszewska-Day (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
