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Contenido archivado el 2024-06-18

"Alpha-helical Barrels: Exploring, Understanding and Exploiting a New Class of Protein Structure"

Objetivo

"Recently through de novo peptide design, we have discovered and presented a new protein structure. This is an all-parallel, 6-helix bundle with a continuous central channel of 0.5 – 0.6 nm diameter. We posit that this is one of a broader class of protein structures that we call the alpha-helical barrels. Here, in three Work Packages, we propose to explore these structures and to develop protein functions within them. First, through a combination of computer-aided design, peptide synthesis and thorough biophysical characterization, we will examine the extents and limits of the alpha-helical-barrel structures. Whilst this is curiosity driven research, it also has practical consequences for the studies that will follow; that is, alpha-helical barrels made from increasing numbers of helices have channels or pores that increase in a predictable way. Second, we will use rational and empirical design approaches to engineer a range of functions within these cavities, including binding capabilities and enzyme-like activities. Finally, and taking the programme into another ambitious area, we will use the alpha-helical barrels to template other folds that are otherwise difficult to design and engineer, notably beta-barrels that insert into membranes to render ion-channel and sensor functions."

Ámbito científico

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.

Convocatoria de propuestas

ERC-2013-ADG
Consulte otros proyectos de esta convocatoria

Régimen de financiación

ERC-AG - ERC Advanced Grant

Institución de acogida

UNIVERSITY OF BRISTOL
Aportación de la UE
€ 2 467 844,00
Dirección
BEACON HOUSE QUEENS ROAD
BS8 1QU Bristol
Reino Unido

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Región
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Tipo de actividad
Higher or Secondary Education Establishments
Investigador principal
Derek Neil Woolfson (Prof.)
Enlaces
Coste total
Sin datos

Beneficiarios (1)