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"Alpha-helical Barrels: Exploring, Understanding and Exploiting a New Class of Protein Structure"

Ziel

"Recently through de novo peptide design, we have discovered and presented a new protein structure. This is an all-parallel, 6-helix bundle with a continuous central channel of 0.5 – 0.6 nm diameter. We posit that this is one of a broader class of protein structures that we call the alpha-helical barrels. Here, in three Work Packages, we propose to explore these structures and to develop protein functions within them. First, through a combination of computer-aided design, peptide synthesis and thorough biophysical characterization, we will examine the extents and limits of the alpha-helical-barrel structures. Whilst this is curiosity driven research, it also has practical consequences for the studies that will follow; that is, alpha-helical barrels made from increasing numbers of helices have channels or pores that increase in a predictable way. Second, we will use rational and empirical design approaches to engineer a range of functions within these cavities, including binding capabilities and enzyme-like activities. Finally, and taking the programme into another ambitious area, we will use the alpha-helical barrels to template other folds that are otherwise difficult to design and engineer, notably beta-barrels that insert into membranes to render ion-channel and sensor functions."

Wissenschaftliches Gebiet

CORDIS klassifiziert Projekte mit EuroSciVoc, einer mehrsprachigen Taxonomie der Wissenschaftsbereiche, durch einen halbautomatischen Prozess, der auf Verfahren der Verarbeitung natürlicher Sprache beruht.

Aufforderung zur Vorschlagseinreichung

ERC-2013-ADG
Andere Projekte für diesen Aufruf anzeigen

Gastgebende Einrichtung

UNIVERSITY OF BRISTOL
EU-Beitrag
€ 2 467 844,00
Adresse
BEACON HOUSE QUEENS ROAD
BS8 1QU Bristol
Vereinigtes Königreich

Auf der Karte ansehen

Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of
Aktivitätstyp
Higher or Secondary Education Establishments
Hauptforscher
Derek Neil Woolfson (Prof.)
Links
Gesamtkosten
Keine Daten

Begünstigte (1)