Objective
Stakes: Availability of adequate test model systems is essential to the development of risk assessment programmes for nuclear receptors-interacting compounds (NR-ICs) (drugs, industrial compounds, cosmetics, environmental contaminants and food components).
Goal: The objective of the EXERA project is to develop novel 3D in vitro models of mouse tissues from five major organs for the pharmaco-toxicological analysis of Estrogen Receptors-Interacting Compounds (ER-ICs): liver, skin and bone (non reproductive systems), ovary and testis (male and female reproductive systems).
Work content: This objective will be pursued through a Work Programme which allies an integrated scientific approach between innovative technologies such as the 3D-culture device, known as "Rotary Cell Culture System" (RCCS Technology adapted to the needs of this project), established transgenic mouse lines (estrogen-reporter mice, here called MOUSE-1) and genomic platforms for ER-ICs characterization. Our strategy is planned around 5 main points including, besides the mentioned technologies, multiple cell cultures quality controls, immortalisation control, cell banking and the use of specific markers of estrogenic action and cell differentiation/health, in order to obtain estrogen-responsive 3D-cultures of well differentiated mouse cells.
Expected Results and Related Benefits: The corresponding work programme will be ensured by an important involvement of the whole partnership and by a high degree of coordination between 7 private and 3 public institutions.
The expected results of our effort will be scientifically, socially and economically relevant:
1) application/adaptation of new 3D-culture technologies to cell cultures devoted to the study of ER-ICs;
2) constitution of a cell bank and, finally
3) a battery of differentiated 3D cell-based systems derived from estrogen-reporter mice for basic and applied research (e.g. pharmacology and toxicology), public use and industrial use.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine toxicology
- medical and health sciences basic medicine pharmacology and pharmacy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BRESCIA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.