Cel Stakes: Availability of adequate test model systems is essential to the development of risk assessment programmes for nuclear receptors-interacting compounds (NR-ICs) (drugs, industrial compounds, cosmetics, environmental contaminants and food components). Goal: The objective of the EXERA project is to develop novel 3D in vitro models of mouse tissues from five major organs for the pharmaco-toxicological analysis of Estrogen Receptors-Interacting Compounds (ER-ICs): liver, skin and bone (non reproductive systems), ovary and testis (male and female reproductive systems). Work content: This objective will be pursued through a Work Programme which allies an integrated scientific approach between innovative technologies such as the 3D-culture device, known as "Rotary Cell Culture System" (RCCS Technology adapted to the needs of this project), established transgenic mouse lines (estrogen-reporter mice, here called MOUSE-1) and genomic platforms for ER-ICs characterization. Our strategy is planned around 5 main points including, besides the mentioned technologies, multiple cell cultures quality controls, immortalisation control, cell banking and the use of specific markers of estrogenic action and cell differentiation/health, in order to obtain estrogen-responsive 3D-cultures of well differentiated mouse cells. Expected Results and Related Benefits: The corresponding work programme will be ensured by an important involvement of the whole partnership and by a high degree of coordination between 7 private and 3 public institutions. The expected results of our effort will be scientifically, socially and economically relevant: 1) application/adaptation of new 3D-culture technologies to cell cultures devoted to the study of ER-ICs; 2) constitution of a cell bank and, finally 3) a battery of differentiated 3D cell-based systems derived from estrogen-reporter mice for basic and applied research (e.g. pharmacology and toxicology), public use and industrial use. Dziedzina nauki medical and health sciencesbasic medicinetoxicologymedical and health sciencesbasic medicinepharmacology and pharmacy Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2005-1.2.3-4 - Development of new in vitro tests to replace animal experimentation Zaproszenie do składania wniosków FP6-2005-LIFESCIHEALTH-7 Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator AZIENDA OSPEDALIERA- SPEDALI CIVILI DI BRESCIA Wkład UE Brak danych Adres P.le Spedali Civili di Brescia BRESCIA Włochy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (8) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITY OF TURKU Finlandia Wkład UE Brak danych Adres Itainen Pitkakatu, 4A TURKU Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ATHLONE INSTITUTE OF TECHNOLOGY Irlandia Wkład UE Brak danych Adres Dublin Road ATHLONE Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych CELLON SA Luksemburg Wkład UE Brak danych Adres 29 Am Becheler BERELDANGE Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych HORMOS MEDICAL OY Finlandia Wkład UE Brak danych Adres Itainen Pitkatu 4 B TURKU Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych DNAVISION Belgia Wkład UE Brak danych Adres rue Adrienne Bolland 8 GOSSELIES Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych BIOUETIKON LIMITED Irlandia Wkład UE Brak danych Adres R&D Building, Dublin City University, Glasnevin DUBLIN 9 Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych ALTA SRL Włochy Wkład UE Brak danych Adres Via Fiorentina 1 SIENA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITA DEGLI STUDI DI MILANO Włochy Wkład UE Brak danych Adres Via Festa del Perdono, 7 MILAN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych