Obiettivo Stakes: Availability of adequate test model systems is essential to the development of risk assessment programmes for nuclear receptors-interacting compounds (NR-ICs) (drugs, industrial compounds, cosmetics, environmental contaminants and food components). Goal: The objective of the EXERA project is to develop novel 3D in vitro models of mouse tissues from five major organs for the pharmaco-toxicological analysis of Estrogen Receptors-Interacting Compounds (ER-ICs): liver, skin and bone (non reproductive systems), ovary and testis (male and female reproductive systems). Work content: This objective will be pursued through a Work Programme which allies an integrated scientific approach between innovative technologies such as the 3D-culture device, known as "Rotary Cell Culture System" (RCCS Technology adapted to the needs of this project), established transgenic mouse lines (estrogen-reporter mice, here called MOUSE-1) and genomic platforms for ER-ICs characterization. Our strategy is planned around 5 main points including, besides the mentioned technologies, multiple cell cultures quality controls, immortalisation control, cell banking and the use of specific markers of estrogenic action and cell differentiation/health, in order to obtain estrogen-responsive 3D-cultures of well differentiated mouse cells. Expected Results and Related Benefits: The corresponding work programme will be ensured by an important involvement of the whole partnership and by a high degree of coordination between 7 private and 3 public institutions. The expected results of our effort will be scientifically, socially and economically relevant: 1) application/adaptation of new 3D-culture technologies to cell cultures devoted to the study of ER-ICs; 2) constitution of a cell bank and, finally 3) a battery of differentiated 3D cell-based systems derived from estrogen-reporter mice for basic and applied research (e.g. pharmacology and toxicology), public use and industrial use. Campo scientifico medical and health sciencesbasic medicinetoxicologymedical and health sciencesbasic medicinepharmacology and pharmacy Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2005-1.2.3-4 - Development of new in vitro tests to replace animal experimentation Invito a presentare proposte FP6-2005-LIFESCIHEALTH-7 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore AZIENDA OSPEDALIERA- SPEDALI CIVILI DI BRESCIA Contributo UE Nessun dato Indirizzo P.le Spedali Civili di Brescia BRESCIA Italia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF TURKU Finlandia Contributo UE Nessun dato Indirizzo Itainen Pitkakatu, 4A TURKU Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ATHLONE INSTITUTE OF TECHNOLOGY Irlanda Contributo UE Nessun dato Indirizzo Dublin Road ATHLONE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CELLON SA Lussemburgo Contributo UE Nessun dato Indirizzo 29 Am Becheler BERELDANGE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato HORMOS MEDICAL OY Finlandia Contributo UE Nessun dato Indirizzo Itainen Pitkatu 4 B TURKU Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato DNAVISION Belgio Contributo UE Nessun dato Indirizzo rue Adrienne Bolland 8 GOSSELIES Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato BIOUETIKON LIMITED Irlanda Contributo UE Nessun dato Indirizzo R&D Building, Dublin City University, Glasnevin DUBLIN 9 Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ALTA SRL Italia Contributo UE Nessun dato Indirizzo Via Fiorentina 1 SIENA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI MILANO Italia Contributo UE Nessun dato Indirizzo Via Festa del Perdono, 7 MILAN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato