Objective Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruption & death. We will identify markers for PET risk prediction in the 1st trimester to allow longer time for tailoring putative medications to prevent PET; and assess & characterize plausible links between marker shortage/access, PET & putative medications in in vitro systems to fit putative medications to pre-defined disease-risk women. Candidates for 1st trimester risk prediction of PET (cell free DNA & RNA, serum PP13, ADAM12, PAPP-A) will be verified with new ones using genomics & proteomics. Our blood, urine & fixed placenta tissue banks of pregnant women enable comparative analysis to build integrative, non-invasive Marker Effectiveness Profiles (MEPs) to PET subtypes (early/late onset, mild/severe, HELLP & IUGR). Disease progressions will be detected by continuous marker monitoring. Expertise in trophoblast in-vitro systems (placenta explants & cell lines) and quantitative real time PCR, genomics & proteomics, immunohistochemistry & confocal microscopy will verify markers' roles and identify links to curing effects of putative medications. We will model 'Putative Medication Benefit Arrays' (PMBAs) for PET subtypes matched to MEPs. We will develop non-invasive diagnostic kits for 1st trimester PET prediction based on markers, antibodies, oligos & siRNA and others coupled to the power of Doppler ultrasound. Nested case-control clinical studies will test effectiveness of combined diagnosis & drug tailoring. Trans-European prospective clinical study, combining early diagnosis & randomising putative medication will verify findings. R&D results will be used to train physicians & patients, to implement new prenatal care practice and eradicate preeclampsia.' Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineobstetricsfetal medicinenatural sciencesphysical sciencesopticsmicroscopyconfocal microscopynatural sciencesphysical sciencesacousticsultrasound Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2005-1.2.2-4 - Development of new diagnostics Call for proposal FP6-2005-LIFESCIHEALTH-7 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator DIAGNOSTIC TECHNOLOGIES LTD. Address 2 ha'carmel street Yoqne'am Israel See on map Links Website Opens in new window EU contribution € 0,00 Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all GLOBAL RESEARCH AND FINANCING Israel EU contribution € 0,00 Address 15, balfour street Tel-aviv See on map Links Website Opens in new window BARKING, HAVERING & REDBRIDGE HOSPITALS NHS TRUST United Kingdom EU contribution € 0,00 Address Harold wood hospital, gubbins lane Romford, essex See on map Links Website Opens in new window MEDICAL UNIVERSITY OF GRAZ Austria EU contribution € 0,00 Address Universitaetsplatz 3 Graz See on map Links Website Opens in new window SEMMELWEIS EGYETEM Hungary EU contribution € 0,00 Address Ülloi u. 26 Budapest See on map Links Website Opens in new window WALLAC OY Finland EU contribution € 0,00 Address Mustionkatu 6 Turku See on map Links Website Opens in new window FOETAL MEDICINE FOUNDATION United Kingdom EU contribution € 0,00 Address 137 harley street London See on map Links Website Opens in new window INNOMEDICA OY LTD. Finland EU contribution € 0,00 Address Tykistökatu 6 b Turku See on map Links Website Opens in new window IMUNOSTAR - INVESTIGAÇÃO E COMERCIALIZAÇÃO DE PRODUTOS DE BIODIAGÓSTICO S.A. Portugal EU contribution € 0,00 Address Rua do campo alegre, 823 Porto See on map UNIVERSITÀ DEGLI STUDI DI MILANO Italy EU contribution € 0,00 Address Via festa del perdono 7 Milano See on map Links Website Opens in new window UNIVERSITÄT BASEL Switzerland EU contribution € 0,00 Address Petersplatz 1 Basel See on map Links Website Opens in new window