Obiettivo An intense line of current investigation in cancer is based on the connection between tumorigenesis and stem cell biology. Some tumours may originate from the transformation of normal stem cells at least in the case of blood, breast, skin, brain, spino-cerebellar and colon cancers. In addition, tumours may contain 'cancer stem cells', rare cells with indefinite potential for self-renewal, that drive tumorigenesis. Interestingly, the same signalling pathways (TGF-beta/BMP, Wnt and Notch pathways) appear to regulate self-renewal in stem cells and cancer cells. Self-renewal occurs through the asymmetric cell division of stem cells, which thereby generate a daughter stem cell and another daughter cell that contributes to populate the developing organ or the growing tumour.In the Drosophila nervous system, one of the best understood asymmetric cell division models; asymmetry is mediated by a biased Notch-dependent signalling event between the two daughter cells. ONCASYM Partners have recently showed i) that the process of biased signalling during asymmetric cell division is controlled by endocytosis and ii) that tumours can be induced in mutants with altered stem-cell asymmetric division. In human normal and cancer stem cells, asym. cell division is supposed to take place, but it has not directly been proved yet. Furthermore, the role of biased signalling by endocytosis in these stem cells has not been addressed to date.The aim of this proposal is 3-fold:i) to screen for genes involved in asymmetric cell division of human cancer stem cells,ii) to characterize the asym. cell division of these stem cells by using these candidate genes as markers and developing novel specific biosensors andiii) to functionally study the role of the identified candidate genes during asym. cell division of cancer stem cells.Our ultimate goal is to untangle the molecular machinery of cancer stem cell asymmetric division thereby providing drugable targets for cancer therapy. Campo scientifico natural sciencesbiological sciencesneurobiologyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsnatural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologycolorectal cancer Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2005-2.2.0-5 - Exploring the patient's cancer stem cell as a novel therapeutic target Invito a presentare proposte FP6-2005-LIFESCIHEALTH-6 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITÉ DE GENÈVE Contributo UE Nessun dato Indirizzo 24, rue du Général-Dufour GENÈVE 4 Svizzera Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto HUBRECHT LABORATORY, NETHERLANDS INSTITUTE FOR DEVELOPMENTAL BIOLOGY / KNAW Paesi Bassi Contributo UE Nessun dato Indirizzo Uppsalalaan 8 UTRECHT Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE Italia Contributo UE Nessun dato Indirizzo Via Adamello, 16 MILAN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ISTITUTO EUROPEO DI ONCOLOGIA SRL Italia Contributo UE Nessun dato Indirizzo Via Filodrammatici, 10 MILAN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUTE OF MOLECULAR BIOTECHNOLOGY OF THE AUSTRIAN ACADEMY OF SCIENCES Austria Contributo UE Nessun dato Indirizzo Dr. Bohrgasse 3-5 VIENNA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT DE RECERCA BIOMEDICA Spagna Contributo UE Nessun dato Indirizzo Baldiri Reixac, 10-12 BARCELONA Mostra sulla mappa Costo totale Nessun dato GALAPAGOS B.V. Paesi Bassi Contributo UE Nessun dato Indirizzo Darwinweg 24 P.O. Box 127 LEIDEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. REPRESENTED BY THE MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS Germania Contributo UE Nessun dato Indirizzo Hofgartenstr. 8 MÜNCHEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato