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Content archived on 2024-05-29

Glycans in body fluids - potential for disease diagnostics

Objective

GLYFDIS mission is to develop novel diagnostic tools for early diagnosis & monitoring cancerous states based on glycome analysis of blood samples. Diagnosis of cancer in its early stages influences many aspects of life. It significantly decreases cancer-associated morbidity & mortality. It relieves eomical & mental burden from patients, their families & society. Accurate monitoring of cancerous states following diagnosis can significantly tribute to prognosis determination and on-line evaluation of therapeutic regimens. GLYFDIS main objectives are: (i) optimisation of different glycome analysis methodologies for mixture of glycomolecules (ii) identifying cancer-associated glycome markers in serum samples of prostate and pancreatic cancer patients (iii) developing and validating protocols and lectin-based microarrays intended for large scale screening of cancer-associated glycome markers in serum samples and (iv) structing a website and a glycome bio-bank integrating GLYFDIS results and serving as a basis for a tinuously growing public glycome data bank. GLYFDIS will make use of glycans (glycome). Their unique diverse ability compared to genome or proteome makes the glycans ideal for diagnosis and monitoring of cancer. Cancer-associated changes in the glycome of the tumoural tissue are very frequent. Currently the main hindrance could be the present glycome-analysis technologies that fall behind the rapidly developing genome- and proteome-analysing technologies. GLYFDIS includes world-leading laboratories in glycome analysis and two essential SMEs playing an integral part in the project: an SME which is an expert in glycan microarray technology for user-friendly and eomical glycan analysis and an SME operating in the field of early stage cancer diagnostic tools. Important results such as an accurate cancer-associated glycome analysis and the development of high throughput methodologies and diagnostic tools are expected.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

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FP6-2005-LIFESCIHEALTH-7
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Funding Scheme

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STREP - Specific Targeted Research Project

Coordinator

BEN-GURION UNIVERSITY OF THE NEGEV
EU contribution
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Address
Marcus Family Campus - Ben-Gurion Boulevard
653 BEER-SHEVA
Israel

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Total cost

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Participants (4)

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