Objective The RATstream' consortium will concentrate on the comprehensive phenotypical characterization of rat models of neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD) and spinocerebellar ataxia type 17 (SCA17). Ultimately, the project will deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed by two SMEs and validated independently by two academic partners and individual data will be incorporated into an integrated database developed by a third SME. In a joint effort the groups will develop a comprehensive set of behavioural and physiological phenotyping procedures including PET and DTI technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in rat models of HD, PD, and SCA17. The resulting set of biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies applying novel substances delaying or preventing neurodegeneration.' Fields of science natural sciencesbiological sciencesneurobiologynatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006). Topic(s) LSH-2005-2.1.3-7 - Characterisation and use of animal models for neurological and psychiatric diseases IST - Information society technologies Call for proposal FP6-2005-LIFESCIHEALTH-7 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator EBERHARD-KARLS UNIVERSITÄT TUEBINGEN Address Wilhelmstr. 7 Tübingen Germany See on map Links Website Opens in new window EU contribution € 0,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all NEWBEHAVIOR AG Switzerland EU contribution € 0,00 Address Hardturmstrasse 76 Zürich See on map Links Website Opens in new window TSE SYSTEMS GMBH Germany EU contribution € 0,00 Address Siemensstr. 21 Bad homburg See on map Links Website Opens in new window COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 0,00 Address Rue leblanc 25 Paris See on map Links Website Opens in new window CROSSLINKS BV Netherlands EU contribution € 0,00 Address Dr molewaterplein 50 - p.a. erasmus medical center room ee15.40 Rotterdam See on map Links Website Opens in new window UNIVERSTITEIT ANTWERPEN Belgium EU contribution € 0,00 Address Prinsstraat 13 Antwerp See on map Links Website Opens in new window FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG Germany EU contribution € 0,00 Address Schlossplatz 4 Erlangen See on map Links Website Opens in new window TROPHOS SA France EU contribution € 0,00 Address Parc scientifique de luminy - luminy biotech entreprises Case 931 Marseille See on map Links Website Opens in new window
