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European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment

Objective

The RATstream' consortium will concentrate on the comprehensive phenotypical characterization of rat models of neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD) and spinocerebellar ataxia type 17 (SCA17). Ultimately, the project will deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed by two SMEs and validated independently by two academic partners and individual data will be incorporated into an integrated database developed by a third SME.

In a joint effort the groups will develop a comprehensive set of behavioural and physiological phenotyping procedures including PET and DTI technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in rat models of HD, PD, and SCA17.

The resulting set of biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies applying novel substances delaying or preventing neurodegeneration.'

Call for proposal

FP6-2005-LIFESCIHEALTH-7
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

EBERHARD-KARLS UNIVERSITÄT TUEBINGEN
Address
Wilhelmstr. 7
Tübingen
Germany

Participants (7)

NEWBEHAVIOR AG
Switzerland
Address
Hardturmstrasse 76
Zürich
TSE SYSTEMS GMBH
Germany
Address
Siemensstr. 21
Bad Homburg
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
Address
Rue Leblanc 25
Paris
CROSSLINKS BV
Netherlands
Address
Dr Molewaterplein 50 - P.a. Erasmus Medical Center Room Ee15.40
Rotterdam
UNIVERSTITEIT ANTWERPEN
Belgium
Address
Prinsstraat 13
Antwerp
FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG
Germany
Address
Schlossplatz 4
Erlangen
TROPHOS SA
France
Address
Parc Scientifique De Luminy - Luminy Biotech Entreprises
Case 931 Marseille