European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment

Objective

The RATstream' consortium will concentrate on the comprehensive phenotypical characterization of rat models of neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD) and spinocerebellar ataxia type 17 (SCA17). Ultimately, the project will deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed by two SMEs and validated independently by two academic partners and individual data will be incorporated into an integrated database developed by a third SME.

In a joint effort the groups will develop a comprehensive set of behavioural and physiological phenotyping procedures including PET and DTI technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in rat models of HD, PD, and SCA17.

The resulting set of biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies applying novel substances delaying or preventing neurodegeneration.'

Fields of science

• medical and health sciences › basic medicine › neurology › parkinson
• agricultural sciences › animal and dairy science › pets
• social sciences › economics and business › business and management › commerce

Programme(s)

• FP6-IST - Information Society Technologies: thematic priority under the specific programme "Integrating and strengthening the European research area" (2002-2006).

Topic(s)

• LSH-2005-2.1.3-7 - Characterisation and use of animal models for neurological and psychiatric diseases
• IST - Information society technologies

Call for proposal

FP6-2005-LIFESCIHEALTH-7
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

EBERHARD-KARLS UNIVERSITÄT TUEBINGEN

Address

Wilhelmstr. 7
Tübingen
Germany

Participants (7)

NEWBEHAVIOR AG

Switzerland

Address

Hardturmstrasse 76
Zürich

TSE SYSTEMS GMBH

Germany

Address

Siemensstr. 21
Bad Homburg

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

Address

Rue Leblanc 25
Paris

CROSSLINKS BV

Netherlands

Address

Dr Molewaterplein 50 - P.a. Erasmus Medical Center Room Ee15.40
Rotterdam

UNIVERSTITEIT ANTWERPEN

Belgium

Address

Prinsstraat 13
Antwerp

FRIEDRICH-ALEXANDER UNIVERSITÄT ERLANGEN-NÜRNBERG

Germany

Address

Schlossplatz 4
Erlangen

TROPHOS SA

France

Address

Parc Scientifique De Luminy - Luminy Biotech Entreprises
Case 931 Marseille