The RATstream' consortium will concentrate on the comprehensive phenotypical characterization of rat models of neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD) and spinocerebellar ataxia type 17 (SCA17). Ultimately, the project will deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed by two SMEs and validated independently by two academic partners and individual data will be incorporated into an integrated database developed by a third SME.
In a joint effort the groups will develop a comprehensive set of behavioural and physiological phenotyping procedures including PET and DTI technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in rat models of HD, PD, and SCA17.
The resulting set of biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies applying novel substances delaying or preventing neurodegeneration.'
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