Objective
Schizophrenia is a devastating neuropsychiatric illness that affects more than one percent of the world's population. Drugs acting in part on dopamine D2 receptors (D2R) are commonly used as medication.
Recent evidence has linked dysregulation of Akt-GSK3 signalling pathways with schizophrenia pathogenesis. Since D2R activation has recently be shown to inhibit Akt in the striatum, this new signalling pathway could contribute to the etiology of schizophrenia and thus represents a new interesting research avenue.
The aim of my project is to better characterize this signalling pathway and identify compounds able to act as selective antagonist in order to counterbalancing a defect of this way. For this purpose, I will
- Identify the different partners of this signalling pathway.
- Screen different antipsychotics and their derivatives in order to identify a selective antagonist of the D2R/Akt pathway.
- Study the selective antagonist effects on different mice models of schizophrenia.
In the return host organization, I will apply knowledge and technical expertise I acquired to apelin signalling. The aim of the project is centred around the desensitization/resensitization of apelin receptor and its relationship to a possible heterodimerization between apelin receptor and structurally related receptors such as CXCR4. Then these results will be validated in vivo in a physiopathological model of vascular plasticity.
My project is based on combined in vitro and in vivo approaches to explain the complex role of dopamine receptors, which are of highest relevance for pathophysiological functions in human brain and identify compounds able to treat neuropsychiatric disorders such as schizophrenia.
To accomplish this, I will learn new techniques such as BRET but also signal transduction pathways analysis in mice brain and behaviour, which will complement my previous experience and will be appropriate to establish myself as an independent researcher for my return to France.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine neurology parkinson
- medical and health sciences clinical medicine psychiatry schizophrenia
- medical and health sciences clinical medicine oncology pancreatic cancer
- medical and health sciences clinical medicine gastroenterology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
BP 3048 TOULOUSE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.