Objective
The periodic formation of somites along the anteroposterior axis of the embryo involves a molecular oscillator, the segmentation clock, as revealed by the expression of cyclic genes in the presomitic medoderm. Notch signalling controls cyclic gene expression, but it is not clear yet whether it operates as a component of the clock, a regulator of it, or both.
The project I will develop in the Amacher laboratory at the University of California at Berkeley aims at better understanding the molecular mechanisms controlling the clock. First, in order to identify new molecules involved in the clock control, I will characterize two zebrafish mutations recently identified in the Amacher laboratory that likely disrupt new regulators of the cyclic genes.
Second, I will analyze at a single cell level how Notch signalling and individual components of this pathway control segmentation. For this, I will develop real-time reporters of the clock activity (tools currently greatly needed in the somitogenesis field) and examine with time lapse imaging how oscillations of the clock in individual cells are affected when Notch signalling is impaired in those cells or their neighbours.
From my previous MSc and PhD work, I became familiar with the fields of somitogenesis and neural induction and with the chick and Xenopus models. The Amacher laboratory will offer me a strong scientific environment to broaden my knowledge in patterning questions, learn zebrafish techniques and improve my international experience, in a renowned institution.
After my post-doc, I will be able to establish the zebrafish model in the group of Laurent Kodjabachian at the Institute for Developmental Biology of Marseille, and develop novel approaches to study early fate decisions in the Vertebrate embryo.
I will apply imaging and genetic methods learnt at Berkeley to study the link between differentiation and cell behaviour, a problem, which largely remains to be explored.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences developmental biology
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine embryology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.