Objective
Integral helical membrane proteins constitute about 20% of all proteins encoded by most genomes and they play crucial role in cell function and communication. In addition, the medical importance of membrane bound receptors, channels, and pumps as targets f or drugs are well established.
However, several experimental reasons makes it difficult to obtain the structure of membrane proteins, only 0.6% (168 out of 28,000) of the solved protein structures in the Protein Data Bank (PDB) are membrane proteins. This highlights the need for better and more accurate theoretical structure prediction methods for membrane proteins.
Recently, there has been significant progress in structure prediction of globular proteins from sequence (de novo prediction), offering some hope that structure prediction methodology may be able to contribute to the understanding membrane protein structure.
In this project, currently the best method to predict the structure of non-membrane proteins, the ROSETTA de novo structure prediction method, will be adapted and optimized to predict the three-dimensional structure of membrane proteins.
This project has the potential to significantly enhance the accuracy of the current structural models of membrane proteins (today mostly restricted to 2D topology maps).
It also has the potential to provide fundamentally new insights of high biological and biomedical relevance. From a European perspective there is a chance to acquire expertise in an area of key importance in the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics topology
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.