Skip to main content
Vai all'homepage della Commissione europea (si apre in una nuova finestra)
italiano it
CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-05-29

Role of the Wnt/b-catenin pathway in the dorso-ventral organisation of the telencephalon

Obiettivo

The complexity of the forebrain makes it a challenging task to elucidate how this structure forms during embryonic development. We are beginning to understand how a simple ectodermal sheet gives rise to the functional forebrain. Its most intricate structure is the telencephalon-derived cortex.

A crucial step in forming the cortex is the establishment of distinct dorso-ventral (DV) cell identities. This process is regulated by Hedgehog (Hh) signalling as its abrogation prevents formation of ventral telencephalon.

However, the DV organisation is restored in the absence of both Hh signalling and its repressor Gli3, indicating that another mechanism is able to establish the DV polarity in this context. Here, we propose that this is achieved via the Wnt/b-catenin signalling pathway.

We aim to elucidate
- the mechanisms by which this pathway regulates the DV telencephalic patterning and
- the nature of the interactions existing between Hh and Wnt/b-catenin signalling in this process.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP6-2005-MOBILITY-5
Vedi altri progetti per questo bando

Meccanismo di finanziamento

EIF - Marie Curie actions-Intra-European Fellowships

Coordinatore

KING 'S COLLEGE LONDON
Contributo UE
Nessun dato
Costo totale
Nessun dato