Objective
Lactococcus is a commercially important microorganism. It is used widely in the dairy industry. Cheese quality depends on the raw material, starter cultures and fermentation conditions (T, humidity, NaCl and pH). Redox potential has an important role in the final properties of fermented dairy products, especially their aroma. One possible explanation is the observed effect of redox potential on amino acid catabolism.
The improvement of Lactococcus for industrial purposes involves identifying and controlling the global regulatory circuits responsible for the environmental stress response. In aerobic environments, many metabolic reactions in the cell depend on the balance between oxidative and non-oxidative states which can regulate enzyme activity. Toxic radicals formed by oxygen cause cellular damage and may result in cell death or alter growth. Resistance to these negative effects includes maintaining the redox balance within the cell and the production of detoxifying enzymes.
Lactococcus lactis is known for its powerful reducing activity in milk which occurs before acidification. But little is known about what these activities are and how they are controlled. Our hypothesis is that the acidification kinetics and growth can be altered by manipulating the environmental redox potential. We will investigate this by separating the effects of oxidation stress produced by oxygen from those produced specifically by redox potential.
Environmental stress response is a complex process that can only be addressed by a genome-wide search for the individual but interlinked components. This project will combine physiology, biochemistry, molecular genetics and transcriptome analysis. It will result in new information on redox regulated genes in Lactococcus lactis. This knowledge will increase our ability to control milk and cheese fermentation processes resulting in more efficient and consistent production of high quality dairy foods with improved organoleptic properties.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences molecular biology molecular genetics
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences genetics RNA transcriptomes
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
N/A NORWICH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.