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Contenido archivado el 2024-05-29

Functional assessment of newly identified transcription factors whose expression strongly correlates with telomerase repression

Objetivo

While 90% of cancer cells significantly express telomerase, an enzymatic complex responsible for the maintenance of telomeres, its activity is not detected in normal somatic cells. Expression of the catalytic component of the telomerase complex, hTERT (human Telomerase Reverse Transcriptase), is the limiting factor for telomerase activity, and plays a fundamental role in cellular immortalisation.

The knowledge of factors and mechanisms controlling hTERT transcription is crucial to understanding the telomerase reactivation process, a key step during oncogenesis, and could bring to light new molecular targets for anticancer therapy. Our ambitious project contributes to this task by using cutting-edge techniques of cellular and molecular biology.

Ámbito científico (EuroSciVoc)

Palabras clave

Tema(s)

Convocatoria de propuestas

FP6-2004-MOBILITY-11
Consulte otros proyectos de esta convocatoria

Régimen de financiación

ERG - Marie Curie actions-European Re-integration Grants

Coordinador

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Aportación de la UE
Sin datos
Dirección
251, rue du Faubourg Saint-Martin
PARIS
Francia
Coste total
Sin datos