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Functional assessment of newly identified transcription factors whose expression strongly correlates with telomerase repression

Obiettivo

While 90% of cancer cells significantly express telomerase, an enzymatic complex responsible for the maintenance of telomeres, its activity is not detected in normal somatic cells. Expression of the catalytic component of the telomerase complex, hTERT (human Telomerase Reverse Transcriptase), is the limiting factor for telomerase activity, and plays a fundamental role in cellular immortalisation.

The knowledge of factors and mechanisms controlling hTERT transcription is crucial to understanding the telomerase reactivation process, a key step during oncogenesis, and could bring to light new molecular targets for anticancer therapy. Our ambitious project contributes to this task by using cutting-edge techniques of cellular and molecular biology.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP6-2004-MOBILITY-11
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Meccanismo di finanziamento

ERG - Marie Curie actions-European Re-integration Grants

Coordinatore

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Contributo UE
Nessun dato
Indirizzo
251, rue du Faubourg Saint-Martin
PARIS
Francia
Costo totale
Nessun dato