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Functional assessment of newly identified transcription factors whose expression strongly correlates with telomerase repression

Objectif

While 90% of cancer cells significantly express telomerase, an enzymatic complex responsible for the maintenance of telomeres, its activity is not detected in normal somatic cells. Expression of the catalytic component of the telomerase complex, hTERT (human Telomerase Reverse Transcriptase), is the limiting factor for telomerase activity, and plays a fundamental role in cellular immortalisation.

The knowledge of factors and mechanisms controlling hTERT transcription is crucial to understanding the telomerase reactivation process, a key step during oncogenesis, and could bring to light new molecular targets for anticancer therapy. Our ambitious project contributes to this task by using cutting-edge techniques of cellular and molecular biology.

Champ scientifique (EuroSciVoc)

Mots‑clés

Thème(s)

Appel à propositions

FP6-2004-MOBILITY-11
Voir d’autres projets de cet appel

Régime de financement

ERG - Marie Curie actions-European Re-integration Grants

Coordinateur

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Contribution de l’UE
Aucune donnée
Adresse
251, rue du Faubourg Saint-Martin
PARIS
France
Coût total
Aucune donnée