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CellPROM - Cell Programming by Nanoscaled Devices

Objective

We will develop a new generation of nano-biotechnological equipment, the CellPROMs. As the EPROM paved the way to a broad application of microelectronics, CellPROMs will overcome current limits of and revolutionise the existing handling technologies and procedures by automated, compact and parallel yet still individual handling of large numbers of cellular samples.

Typical targets will be animal and human adult stem cells. Human embryonic stem cells will not be used. The main task of our IP is to develop procedures and devices for the precise creation of NanoScapes - individually tailored nanoscaled macromolecular landscapes, which will allow, for the first time, to non-invasively produce well-defined populations of individually programmed cells, eventually leading to substantial breakthroughs and numerous applications in the fields of molecular medicine and cellular nano-biotechnology. Although surface imprinting of cells will be realised via artificial nano-biotechnological devices, e.g. nanostructured stamps or beads, these tools are designed according to the natural principles of cellular signalling and differentiation. As nanocomponents are essential to the imprinting process, suitable techniques and principles to form nanoscaled macromolecular patterns on arbitrary surface geometries have to be developed. All components, ranging from the nanoscale of functional interfaces up to the macro level for cell handling, are to be developed as functional modules suitable for further application.

The project features multiple nano- and biotechnological challenges. To tackle these, will lead to breakthroughs in nanotechnological device development and, moreover, drastically advance our understanding of biological signals relevant to cellular programming. Once available, CellPROMs will facilitate the transition to a more knowledge-based and less resource-intensive society in Europe.

Call for proposal

FP6-2002-NMP-1
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Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27c
Muenchen
Germany

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EU contribution
No data

Participants (26)