Objective
Structure Based Protein Fold Recognition Using Dynamic Bayesian Networks Today it remains impossible to predict the three-dimensional structure of a protein based on its amino acid sequence alone. The ability to predict protein structure from sequence would have great impact on crucial areas ranging from understanding protein function over protein design to drug development. To simplify the problem, fold recognition methods try to evaluate the possibility that a query sequence adopts any of the already known folds (the template folds). This is already extremely useful, since knowing that a sequence likely corresponds to a certain fold can e.g. lead to the elucidation of the protein's function. This can e.g. be used to perform gene annotation on a genomic scale. We propose to construct a novel structure based protein fold recognition method that uses a probabilistic description of protein structure using Dynamic Bayesian Networks (Dens), a machine learning method for which efficient methods exist to perform inference and parameter learning from data. This will allow us to construct probabilistic models that are in many ways more advanced than currently used techniques. In particular, we will develop Dens that represents local amino acid preference, local backbone structure, residue exposure and no local residue-residue contacts of a 'general' protein structure. These probabilistic models can then be used to evaluate the fit between a given sequence family superimposed on a specific structure, le. As a scoring function in a fold recognition method.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences organic chemistry amines
- natural sciences computer and information sciences artificial intelligence machine learning
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
COPENHAGEN K
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.