Objective
The project EUGINDAT is an integrated approach that links genetics, biochemistry, physiology, genomics, proteomics, structural biology, drug development and clinical studies in an attempt to improve understanding and treatment of Primary Inherited Aminoacidurias (PIA). PIA are rare diseases involving defects in renal reabsorption of amino acids that also affect other organs. The generation of amino acid or peptide transporter-deficient mice will have an impact on our knowledge not only of renal reabsorption but also nutrition, and pathological states such as certain forms of cachexia and selected disorders of the central nervous system. The main objectives are: 1) To complete a clinical and molecular-genetic description of PIA with the generation of a European PIA-DATABASE including: Cystinuria, Lysinuric Protein Intolerance (LPI), Dicarboxylic Aminoaciduria (DA), Hartnup Disorder (HDis), Iminoglycinuria (IG) and "unlabeled aminoacidurias". The proposal aims to study candidate genes for cystinuria, DA, HDis and IG. 2) To gain a thorough knowledge of the molecular structure of relevant transporters using 2D crystals of prokaryotic, and eventually eukaryotic, homologues and 3D crystals of water-soluble extracellular domains. 3) To complete a functional genomic study of relevant transporters underlying PIA and renal reabsorption of amino acids. 4) To identify genes and/or loci that affect cystinuria lithiasis, and may eventually explain gender-related and individual variability in stone-forming activity in patients with cystinuria. 5) To develop new therapeutic strategies for cystinuria lithiasis. 6) To identify the mechanisms contibuting to the pathology of LPI which explain the hepatic phenotype (hyperammonemia) and the immune system-compromising symptoms. 7) To test new therapeutic approaches for the life threatening complications of LPI.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine nephrology
- medical and health sciences health sciences nutrition
- medical and health sciences basic medicine pathology
- natural sciences chemical sciences organic chemistry amines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.