Objective
The present understanding of cellular signal transduction is restricted, at the best, to the wiring schemes of signalling pathways. Little is known about the details of their dynamic operation and the importance of quantitative, spatial and time-dependent parameters for signalling output. Those are, however, crucially important for drug discovery and application. QUASI is a multidisciplinary project with the goal to obtain a coherent and detailed picture of the dynamic operation of a model signalling transduction network. The signalling pathways contain the evolutionary conserved MAP kinase cascade module, which is of central importance for signalling in human cells and implicated in human diseases such as cancer and inflammatory disorders. MAP kinase pathways are currently being explored as drug targets. A better understanding of the dynamic operation of these pathways offers new opportunities for drug discovery and for efficient individualised treatment based on the genetic setup of the patient (pharmacogenomics). To achieve the goals of QUASI, quantitative data of high definition on signal transduction activation and deactivation will be obtained using frontline experimental approaches encompassing global gene expression, proteomics, bioimaging and chemical genetics. A software-implemented mathematical model of signalling dynamics will be constructed from pre-existing data and data generated within the consortium. Predictions from the model will be used as a basis for experimentation to further enhance the model, in a recursive manner. An interactive dynamic visual interface will be constructed to allow the experimenter to explore the effects of virtual manipulations of the system. This tool will enhance the intuitive understanding of intracellular signalling and this interface could be developed into a general tool for education as well as prediction of drug effects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences mathematics applied mathematics mathematical model
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
100 GOETEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.