Cel The present understanding of cellular signal transduction is restricted, at the best, to the wiring schemes of signalling pathways. Little is known about the details of their dynamic operation and the importance of quantitative, spatial and time-dependent parameters for signalling output. Those are, however, crucially important for drug discovery and application. QUASI is a multidisciplinary project with the goal to obtain a coherent and detailed picture of the dynamic operation of a model signalling transduction network. The signalling pathways contain the evolutionary conserved MAP kinase cascade module, which is of central importance for signalling in human cells and implicated in human diseases such as cancer and inflammatory disorders. MAP kinase pathways are currently being explored as drug targets. A better understanding of the dynamic operation of these pathways offers new opportunities for drug discovery and for efficient individualised treatment based on the genetic setup of the patient (pharmacogenomics). To achieve the goals of QUASI, quantitative data of high definition on signal transduction activation and deactivation will be obtained using frontline experimental approaches encompassing global gene expression, proteomics, bioimaging and chemical genetics. A software-implemented mathematical model of signalling dynamics will be constructed from pre-existing data and data generated within the consortium. Predictions from the model will be used as a basis for experimentation to further enhance the model, in a recursive manner. An interactive dynamic visual interface will be constructed to allow the experimenter to explore the effects of virtual manipulations of the system. This tool will enhance the intuitive understanding of intracellular signalling and this interface could be developed into a general tool for education as well as prediction of drug effects. Dziedzina nauki natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencescell biologycell signalingnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsnatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencesmathematicsapplied mathematicsmathematical model Słowa kluczowe MAP kinases Signal transduction cellular dynamics mathematical models Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2002-1.1.0-1 - Topics for Specific Targeted Research Project/CA in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Zaproszenie do składania wniosków FP6-2002-LIFESCIHEALTH Zobacz inne projekty w ramach tego zaproszenia System finansowania STREP - Specific Targeted Research Project Koordynator GOETEBORG UNIVERSITET Wkład UE Brak danych Adres Vasaparken 100 GOETEBORG Szwecja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITAT POMPEU FABRA Hiszpania Wkład UE Brak danych Adres ¨Placa de la Merce, 12 BARCELONA Zobacz na mapie Koszt całkowity Brak danych INSTITUT FUER BIOCHEMIE UND MOLEKULARE ZELLBIOLOGIE DER UNIVERSITAET WIEN Austria Wkład UE Brak danych Adres Dr. Bohrgasse 9 WIEN Zobacz na mapie Koszt całkowity Brak danych EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Szwajcaria Wkład UE Brak danych Adres Raemistrasse 101 ZURICH Zobacz na mapie Koszt całkowity Brak danych MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Niemcy Wkład UE Brak danych Adres Hofgartenstrasse 8 101062 MUENCHEN Zobacz na mapie Koszt całkowity Brak danych MAELARDALENS HOEGSKOLA Szwecja Wkład UE Brak danych Adres SANKTA URSULAS VAEG 2A 883 VAESTERAAS Zobacz na mapie Koszt całkowity Brak danych