Objective
The complete sequence of a mammalian genome defines the total information content. The next major challenge is to understand how the information is used in subsets during development - subsets that define multipotential states (stem cells); subsets that define differentiated states; and how the transitions between these states are made (lineage commitment). The research partnership, FunGenES, will address this challenge. FunGenES will map, using both expression profiling and high throughput functional screens, the subsets used in pluripotent, lineage committed and selected differentiated cell types to make an atlas of mammalian genome utilization in early development. The remarkable properties of mouse ES cells are key to the proposal. These cells are pluripotent, can be differentiated through the three major developmental pathways; ecto- endo- and mesoderm, to many differentiated cell types, and can be engineered. Manipulation of mouse ES cells also presents paradigms for the development of cell therapies. To accomplish this next, major, milestone in human biology, we have assembled a team of leading academic and commercial experts in the major pathways of ES cell differentiation, anchored by common services provided by world leaders in three technology areas. These areas are - BAC transgene engineering (for efficient production of lineage reporter and selectable lines), RNAi (esiRNA; for high throughput functional screens) and database management of expression profiling. Because these resources are centralized, and methodologies are unified for all of FunGenES, the substantial aim to generate a functional and expression atlas database will be accomplished efficiently. The atlas is the first goal. It will provide hypotheses for testing with advanced functional tools. By understanding how mammalian genomic information is selectively used in development, we will acquire an essential key to understanding ourselves, and our health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine neurology parkinson
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-LIFESCIHEALTH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
KÖLN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.