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Recombinant Pharmaceuticals from Plants for Human Health

Obiettivo

Plants are attractive vehicles for the expression of recombinant pharmaceutical proteins as they are inexpensive and versatile systems, amenable to rapid and economical scale-up. Public opinion in Europe is generally negative towards GM plants, which has led to the loss of many SMEs and commercial development from the Union. However, the use of GM plants for medicines and vaccines rates very highly in terms of public acceptance. With this proposal, our primary aim is to build on previous proof-of-concept studies to develop pharmaceutical products through to clinical trials. The use of GM pharmaceuticals has precedents, such as human insulin and hepatitis B vaccine, but plant-derived materials used in humans has not been formally addressed within the EU. A major outcome will be to define the regulatory requirements through a process of engagement and consultation with all relevant regulatory bodies (involved in GM plants as well as new pharmaceuticals), in order to move through clinical trials and gain permission for the use of plant derived pharmaceuticals in practice. Monoclonal antibodies will be the first generation of molecules to be developed for Phase I clinical evaluation, and we include 2 neutralising antibodies each for HIV and rabies. The proposal also includes a limited range of other targets, against HIV, TB and diabetes, and for some of these, new expression strategies will need to be developed. They represent the second-generation molecules, which will feed the development pipeline for SMEs in Europe, beyond the lifetime of the project. In each case, plant-based systems offer a real advantage, if not the only option for production on a scale relevant to the needs for that molecule. Alongside our principle aim of developing plant derived recombinant pharmaceuticals, we recognise the need to put in place comprehensive risk assessments based on health and environmental impacts, and to work with EU regulatory authorities.

Campo scientifico

  • /scienze agricole/biotecnologia agricola/genetica agraria
  • /scienze mediche e della salute/medicina di base/farmacologia e farmacia/farmaco

Invito a presentare proposte

FP6-2002-LIFESCIHEALTH
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Meccanismo di finanziamento

IP - Integrated Project

Coordinatore

FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Indirizzo
Hansastrasse 27C
München
Germania

Partecipanti (31)

ST. GEORGE'S HOSPITAL MEDICAL SCHOOL'
United Kingdom
Indirizzo
Cranmer Terrace,
London
RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE
Germania
Indirizzo
Templergraben 55
Aachen
NATIONAL UNIVERSITY OF IRELAND, MAYNOOTH
Irlanda
Indirizzo
(None)
Maynooth, Co. Kildare
JOHN INNES CENTRE
United Kingdom
Indirizzo
Norwich Research Park, Colney
Norwich
CENTRE DE COOPÉRATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DÉVELOPPEMENT
Francia
Indirizzo
Rue Scheffer, 42
Paris
OXFORD BROOKES UNIVERSITY
United Kingdom
Indirizzo
Gipsy Lane, Headington
Oxford
UNIVERSITY OF WARWICK
United Kingdom
Indirizzo
Gibbett Hill Road
Coventry
UNIVERSITÄT FÜR BODENKULTUR
Austria
Indirizzo
Gregor-mendelstrasse 33
Vienna
POLYMUN SCIENTIFIC IMMUNBIOLOGISCHE FORSCHUNG GMBH
Austria
Indirizzo
Nussdorfer Lände 11
Vienna
UNIVERSITA' DEGLI STUDI DI VERONA
Italia
Indirizzo
Via Dell' Artigliere 8
Verona
ENTE PER LE NUOVE TECHOLOGIE, L'ENERGIA E L'AMBIENTE'
Italia
Indirizzo
Lungotevere Thaon Di Ravel, 76
Roma
UNIVERSITÉ BLAISE PASCAL - CLERMONT-FERRAND II
Francia
Indirizzo
Avenue Camot, 34
BP185 Clermont-ferrand
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Francia
Indirizzo
147 Rue De L'université
Paris
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Indirizzo
The Old Schools, Trinity Lane
Cambridge
UNIVERSITY OF GLASGOW
United Kingdom
Indirizzo
University Avenue
Glasgow
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Germania
Indirizzo
Seminarstrasse 2
105760 Heidelberg
UNIVERSITÉ CATHOLIQUE DE LOUVAIN
Belgio
Indirizzo
Place De L'université, 1
Louvain-la-neuve
UNIVERSITY OF LEEDS
United Kingdom
Indirizzo
Woodhouse Lane
Leeds
CONSIGLIO NAZIONALE DELLE RICERCHE
Italia
Indirizzo
Piazzale Aldo Moro 7
Roma
COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH
Sud Africa
Indirizzo
Meiring Naudee Road
395 Pretoria
ROTHAMSTED RESEARCH
United Kingdom
Indirizzo

Harpenden
UNIVERSITÉ DE NEUCHÂTEL
Svizzera
Indirizzo
Avenue Du 1Er-mars 26
Neuchâtel
MAX-PLANCK-SOCIETY FOR THE ADVANCEMENT OF SCIENCE
Germania
Indirizzo
Hofgartenstr. 8
D-80084 Munich
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN ( HEREINAFTER CALLED TCD)
Irlanda
Indirizzo
The University Of Dublin, Trinity College, College Green
Dublin
INSTITUT FÜR PFLANZENGENETIK UND KULTURPFLANZENFORSCHUNG GATERSLEBEN
Germania
Indirizzo
Corrensstrasse 3
Gatersleben
FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY
Belgio
Indirizzo
Rijvisschestraat 120
Zwijnaarde
CENTRE FOR THE MANAGEMENT OF INTELLECTUAL PROPERTY IN HEALTH REARARCH AND DEVELOPMENT
United Kingdom
Indirizzo
Cheapside House,168 Cheapside
London
MOSAIC SYSTEMS BV
Paesi Bassi
Indirizzo
Markt 44
Prinsenbeek
UNIVERSITAT DE LLEIDA
Spagna
Indirizzo
P. Victor Siurana, 1
Lleida
SARTORIUS AG
Germania
Indirizzo
Weender Landstrasse 94-108
Göttingen
THE UNIVERSITY OF SURREY
United Kingdom
Indirizzo
Stag Hill
Guildford, Surrey