Objective
At present, chitosan tablets are commercially available as over-the-counter dietary supplements for hypercholesterolemia and overweight Nevertheless, their formulation is primitive because the chitosan used is not in the most suitable physical and biochemi cal form. Thus the consumers are forced to take large daily doses, and face exceedingly high costs and poor results. Moreover for celiac disease, no dietary food incorporating chitosan exists. This kind of patients have to use expensive gluten-free dietary foods instead of bread and pasta, with economical, nutritional and psychological distress: all these inconveniences could be removed by a proper incorporation of chitosan. Finally it is likely (but not yet investigated) that colitis patients might have be nefits from chitosan intake, should chitosan be developed into a carrier for colitis-specific drugs. This proposal intends to develop new chitosan physical forms and formulations useful for the prevention and treatment of said widely occurring diseases an d dysfunctions of the digestive system, that eventually develop into serious chronic diseases (hart diseases, obesity, diabetes, malabsorption, Crohn disease) that constitute heavy social burdens. The rationale is that chitosan has to be put into amorphous form, increasing its surface area, porosity, solubility and compressibility: in this way tabletting becomes feasible without the use of binders and higher efficacy is obtained; moreover, the total weight of a tablet is much lower. This will be achieved by spray-drying, freeze-drying and other techniques available in the food industry, involving most recent advances in the chemistry of alkaline chitosan solutions. Assessments will include instrumental analytical chemistry, biochemistry, microbiology and org anoleptic evaluations. As for celiac disease, the rationale resides in the capacity of chitosan to sequester the toxic gliadin fraction responsible for intolerance. Pasta and bakery products containing minor quantities of chitosan would expectedly make the se common foods accessible to celiac patients. Assessments will include analytical chemistry and organoleptic evaluations. Among the final deliveries are the following: a) novel instant soluble, highly effective chitosan formulations; b) very innovative d ietary foods for celiac patients; c) scientifically based description of the oral delivery of chitosan; d) quality standards for chitosan to be used as a dietary supplement; e) dru carriers for aminosalic lic acid; scientificall sound informative material for the consumer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-SME-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NIZHNI NOVGOROD
Russia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.