Objective Diseases of the kidney represent a major cause of morbidity and mortality in Europe. The elderly are disproportionately affected, but renal disease is also a condition that severely affects children. An estimated 4.5 Million Europeans suffer from renal disorders. The death rate in patients with renal failure is 20% annually. This disease burden and its challenge for our societies is the focus of this proposal. Elucidation of the human and other genomes heralds a new era in biomedical research offering unprecedented opportunities to understand disease processes and to identify strategies to improve health. We will embrace these opportunities and implement an interdisciplinary research program, the European Renal Genome Project (EuReGene) that integrates European excellence in research relevant to renal development, pathophysiology and genetics. Our goal is to discover genes responsible for renal development and disease, their proteins and their actions. To achieve this goal, we have established a consortium of leading scientists, clinicians and SME partners that will focus on the development of novel technologies and discovery tools in functional genomics and their application to kidney research. We will rely on comparative genomic studies in many systems that provide utilitarian models ranging from zebrafish, to Xenopus, to mice, to rats. Our studies will be performed at different levels including the gene, the cell, the organ and the organism. Ultimately, identification of disease genes will lead to a better understanding of renal disease processes, to improved diagnosis and to new concepts in therapy. Our program will establish a paradigm for an integrated post-genomic approach to analyze renal disease-related developments that may be transferred to other organ systems or disease entities in the future. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesdiabetic nephropathymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineembryologymedical and health sciencesclinical medicinenephrologykidney diseases Keywords QTL mapping Xenopus cardiovascular diseases complex genetics kidney diseases mouse organogenesis renal pathogenesis solute carrier transcriptome analysis transgenic animal models zebrafish Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.1.5-6 - Functional genomics approaches in animal models to study human immunological disease Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme IP - Integrated Project Coordinator MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN EU contribution No data Address Robert-Roessle-Str., 10 740238 BERLIN Germany See on map Links Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address 20 Park Crescent LONDON See on map Links Website Opens in new window Total cost No data SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZURICH Switzerland EU contribution No data Address Rämistrasse 101 ZÜRICH See on map Links Website Opens in new window Total cost No data ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy EU contribution No data Address Via Eritrea, 62 MILANO See on map Links Website Opens in new window Total cost No data UNIVERSITY OF ZURICH Switzerland EU contribution No data Address Winterthurerstr. 190 ZURICH See on map Links Website Opens in new window Total cost No data UNIVERSITY OF OULU Finland EU contribution No data Address Pentti Kaiteran katu 1 OULU See on map Links Website Opens in new window Total cost No data UNIVERSITY OF AARHUS Denmark EU contribution No data Address Ndr. Ringgade 1 AARHUS C See on map Links Website Opens in new window Total cost No data CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution No data Address University Offices, Wellington Square OXFORD See on map Links Website Opens in new window Total cost No data RECEPTICON APS Denmark EU contribution No data Address Science Park Gustav Wieds Vej 10 AARHUS See on map Links Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE France EU contribution No data Address 101 rue de Tolbiac PARIS See on map Links Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN Germany EU contribution No data Address Geschwister-Scholl-Platz 1 MÜNCHEN See on map Total cost No data MAX-PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN, MPI OF EXPERIMENTAL ENDOCRINOLOGY Germany EU contribution No data Address Hofgartenstrasse 8 MUENCHEN See on map Links Website Opens in new window Total cost No data UNIVERSITÉ CATHOLIQUE DE LOUVAIN Belgium EU contribution No data Address Place de l'Université, 1 LOUVAIN-LA-NEUVE See on map Links Website Opens in new window Total cost No data ZENTRUM FÜR MOLEKULARE NEUROBIOLOGIE, UNIVERSITÄT HAMBURG Germany EU contribution No data Address Martinistrasse 52 HAMBURG See on map Links Website Opens in new window Total cost No data