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DNA damage responses, Genomic instability and Radiation-Induced Cancer: The problem of risk at low and protracted doses (RISC-RAD)

Ziel

Radiation protection requires a thorough understanding of low dose ionising radiation. Currently extrapolation from high doses is necessary to estimate the effects of low doses. Furthermore, it is critically important to have an appreciation of the variation in individual responses to radiation among the human population. Present estimates of the risks from radiation exposure are based largely on the "average" individual in an exposed population. However, clinical observations of adverse reactions to radiotherapy indicate large variations in individual radiosensitivity. Quantification of risk requires the identification of new parameters taking into account these differences in radiation responses. Therefore, a detailed knowledge of the mechanisms by which radiation induces cancer is essential. In this project, leading European research teams join forces to understand the various steps involved in the multistage process of radiation-induced tumourigenesis through detailed analysis of DNA damage responses (repair, checkpoints, apoptosis), genomic instability as well as mechanisms/genetics and modelling of radiation tumourigenesis. The research in this project will answer the following specific questions: (i) Who is at risk? (ii) When do the factors modifying risk exert their influence? (iii) What are the mechanisms through which risk factors act? (iv) Is there a link between radiosensitivity of individuals (short term) and susceptibility to cancer (Late after exposure)? The consortium will apply innovative and state of the art technology (genomics, proteomics, advanced fluorescence microscopy, RNA interference, gene knock-in technology). We stress that the identification of genetic variables in the processing of radiation induced DNA damage is vital for re-evaluation of current radio-protective measures and the development of future protective procedures.

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EURATOMCALL2003-FIXEDDEADLINE
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IP - Integrated Project

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COMMISSARIAT A L'ENERGIE ATOMIQUE
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Frankreich

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Letzte Aktualisierung: 25 Mai 2022

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Permalink: https://cordis.europa.eu/project/id/508842/de

European Union, 2024