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Contenuto archiviato il 2024-05-29

Ex vivo assessment of therapy for brain tumors

Obiettivo

CAPSANT Neurotechnologies is an emerging SME that spun out from the University of Southampton (UK). The scientific and technological basis of the company, that makes its originality and strength on the market, is its unique ability to screen drugs in a fully relevant ex vivo set up.

In this set up, experimental models of-up to now- stroke or epilepsy can be analysed in brain slices maintained in organotypic cultures, and outcome measures of neuronal alteration and death provide quantified clues about the protective effects of pharmacological compounds.

This platform is currently used for high throughput screening by several industrial partners of CAPSANT Neurotechnologies. Independently, the academic team led by Dr Marc Peschanski at INSERM in Creteil, France, has developed in recent years an experimental model based upon an adaptation of the same methodology, that allows analysing potential therapeutics for an additional brain disease, namely glioblastoma.

In addition to allowing proliferation and intra-parenchymal migration of tumour cells to be quantified, this technique (called ISIS for intra-slice implantation system) has revealed instrumental to study tumour-induced angiogenesis. Several molecules endowed with anti-tumoral or anti-angiogenic potentials have already been successfully screened in this set up.

The program proposed for this Marie-Curie fellowship directly stems from the obvious complementarity of the two R and D programs. Collaboration, in particular through extended periods of work by Marc Peschanski and members of his team at CAPSANT, will allow the transfer of technology to the company, extending its offer to industrial partners to screening for therapies applicable to brain tumours.

Conversely, CAPSANT scientists will provide high level training to Marc Peschanski and his team to all techniques they master that allow functional analysis of brain slices, including in particular electrophysiology and proteomics.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP6-2002-MOBILITY-3
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Meccanismo di finanziamento

TOK - Marie Curie actions-Transfer of Knowledge

Coordinatore

CAPSANT NEUROTECHNOLOGIES
Contributo UE
Nessun dato
Indirizzo
2 Venture Rd, Chilworth Science Park
SOUTHAMPTON
Regno Unito
Costo totale
Nessun dato

Partecipanti (1)