Obiettivo Fungal pathogens represent an ever-increasing public health problem, being responsible for nearly 40% of deaths from hospital-acquired infections. These fungal infections are particularly devastating for AIDS patients and other immuno compromised individuals where treatment is rarely curative. Fungal infections are not restricted to animals. Around 10% of the known fungal species are phytopathogens, representing an economic threat causing millions of euros worth of loss to crops. Many pathogenic fungi are dimorphic, that is they can alternate between a unicellular, yeast growth form and a multi-cellular filamentous growth form.Little is known about the molecular mechanisms, which control dimorphic switching, and maintain each growth form. Until recently, the absence of defined genetic tools in dimorphic fungi has meant that investigation of the mechanisms controlling dimorphism has been restricted to model fungi which undertake the multi-cellular touni-cellular switch as part of a broader developmental programme.Pénicillium marneffei displays temperature-dependent dimorphism, being predominantly hyphalin form; as opposed to Candida albicans, which is predominantly yeast. The pathogenic form of P.marneffei is strictly yeast-like. DNA micro-arrays and promoter tagging screen s will allow theidentification of genes responsible for the dimorphic switch and the maintenance of the hyphal and yeast growth forms. Selected genes identified in this project will be 'knocked out' to determine their role in development and pathogenicity.Ustilago mayáis is a phytopathogenic fungus very valuable as a system to study fungaldimorphism and virulence. Contrary to P. marneffei, the pathogenic form of U. mayáis is the filamentous growth. Recently, the crkl gene has been identified to control morphogenesis. Campo scientifico medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesmicrobiologymycologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVagricultural sciencesagriculture, forestry, and fisheriesagriculture Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.2 - Marie Curie Outgoing International Fellowships (OIF) Invito a presentare proposte FP6-2002-MOBILITY-6 Vedi altri progetti per questo bando Meccanismo di finanziamento OIF - Marie Curie actions-Outgoing International Fellowships Coordinatore CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Contributo UE Nessun dato Indirizzo Calle Serrano 117 MADRID Spagna Mostra sulla mappa Costo totale Nessun dato