Development of intervention strategies against sars in a European-Chinese taskforce

Obiettivo

This research proposal is comprehensive, encompassing all the complementary aspects necessary for the development of intervention strategies, including vaccination, immunotherapy, and antivirals to protect against SARS. In addition, techniques and materials will be generated to develop diagnostic kits that will lead to the identification of infected individuals at very early steps of the disease, and to differentiate between vaccinated and naturally infected people. The first focus of the project is vaccine development. Accordingly, a set of complementary strategies is proposed to guarantee the success. These strategies include "classical" vaccines (such as whole inactivated virus), subunit vaccines, and state of the art-recombinant technology derived vaccines. The second focus of the project is on the state of the art-therapeutic approaches, ranging from the use of monoclonal antibodies to specific antivirals. For achieving the primary objectives of this project, the availability of an adequate preclinical setting for SARS-CoV research, including animal models, as well as the access to relevant clinical samples are absolute preconditions. These all met in this project, as a result of the expertise of the individual groups involved. To develop this comprehensive project, laboratories from the European Union and China are collaborating. The laboratories from EU member states (Spain, UK, and The Netherlands), have a long term experience (more than twenty years) in coronavirus pathology, immunology and molecular biology. The groups from China have key knowledge on the onset and evolution of SARS, high technology, and have generated large collections of biological materials: viruses, sera, tissues, clinical and epidemiological data.

Campo scientifico

• scienze mediche e della salute › scienze della salute › malattie infettive › virus a RNA › coronavirus
• scienze mediche e della salute › medicina di base › farmacologia e farmacia › farmaci › vaccini
• scienze mediche e della salute › medicina di base › immunologia › immunoterapia

Parole chiave

• Antivirais
• Diagnostics
• Immunotherapy
• SARS-CoV
• Vaccine

Programma(i)

• FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006.

Argomento(i)

• POLICIES-2.2 - Public health issues, including epidemiology contributing to disease prevention and responses to emerging rare and communicable diseases, allergies, procedures for secure blood and organ donations, non-animal test methods

Invito a presentare proposte

FP6-2003-SSP-2-SARS
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Meccanismo di finanziamento

STIP - Specific Targeted Innovation Project

Coordinatore

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Indirizzo

Serrano, 117
Madrid
Spagna

Collegamenti

Partecipanti (9)

INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY, CHINESE ACADEMY OF SCIENCES

Cina

Indirizzo

Datun Road, Anding Menwai
Beijing

Collegamenti

UTRECHT UNIVERSITY, FACULTY OF VETERINARY MEDICINE

Paesi Bassi

Indirizzo

Yalelaan 1
80.165 Utrecht

Collegamenti

INSTITUTE FOR ANIMAL HEALTH

United Kingdom

Indirizzo

High Street
Compton Compton, Newbury

Collegamenti

ERASMUS MC

Paesi Bassi

Indirizzo

Dr. Molewaterplein 50
1738 Rotterdam

Collegamenti

LABORATORY OF MOLECULAR MEDICINE, COLLEGE OF LIFE SCIENCES, SUN YATSEN UNIVERSITY, GUANGZHOU, CHINA

Cina

Indirizzo

135 West Xingang Road
Guangzhou

Collegamenti

WUHAN INSTITUTE OF VIROLOGY, CHINESE ACADEMY OF SCIENCES

Cina

Indirizzo

Xiaohongsan 44#
Wuhan

Collegamenti

INSTITUTO DE SALUD CARLOS III

Spagna

Indirizzo

Siensio Delgado, 4-6
Madrid

Collegamenti

FORT DODGE VETERINARIA SA

Spagna

Indirizzo

Carretera Camprodon S/n Finca
OLOT-49 Vall De Bianya

Collegamenti

INTERVET UK LTD

United Kingdom

Indirizzo

Walton Manor, Walton
Milton Keynes

Collegamenti