Objetivo The proposal has four key objectives: a) to characterise and quantify the key factors that determine the transmission dynamics of the aetiological agent via epidemiological analysis and clinical studies of material collected from SARS patients, to develop statistical methods to estimate key parameters, and to complete retrospective epidemiological analyses of national or city based databases of the SARS epidemics in Hong Kong, Beijing, and Taiwan that capture the spatial and temporal network structure of mixing between individuals; b) to define ideal structures for case databases to facilitate rapid analysis and interpretation of epidemic trends and the impact of interventions; c) to create a mathematical framework for studying optimal control policies for directly transmitted respiratory tract infectious diseases in both local, country-wide and global contexts, to inform policy makers; d) to develop models for scenario and risk analysis to explore how best to control defined infectious disease epidemics. The proposal builds on past work with collaborators in Hong Kong which facilitated the creation of a structured database for all SARS cases in those regions and Taiwan, and the analysis day by day of the course of the epidemic and the impact of different interventions (Riley et al, Science May 23rd, 2003; Donnelly et al., Lancet, May 7th, 2003). Clinical aspects to be addressed in this proposal include: the typical course of infection in patients of different ages and with various co-morbidities; the infectiousness (level of viral shedding) of patients through time following acquisition of infection; and the distributions of incubation and infectious periods as a function of modifying factors such as age. Epidemiological aspects include the routes of transmission of the virus, and the types of contacts that resulted in transmission. Although much of the research will be focused on SARS, the overall aims include the development of a mathematical... Ámbito científico medical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesmathematicsapplied mathematicsmathematical model Palabras clave Mathematical models contact tracing databases epidemic analysis intervention Programa(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Tema(s) POLICIES-2.2 - Public health issues, including epidemiology contributing to disease prevention and responses to emerging rare and communicable diseases, allergies, procedures for secure blood and organ donations, non-animal test methods Convocatoria de propuestas FP6-2003-SSP-2-SARS Consulte otros proyectos de esta convocatoria Régimen de financiación STIP - Specific Targeted Innovation Project Coordinador IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Aportación de la UE Sin datos Dirección Imperial College London, South Kensington Campus LONDON Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Aportación de la UE Sin datos Dirección 101, rue de Tolbiac PARIS Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos UNIVERSITEIT UTRECHT Países Bajos Aportación de la UE Sin datos Dirección Heidelberglaan 8 80125 UTRECHT Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos DEPARTMENT OF COMMUNITY MEDICINE, THE UNIVERSITY OF HONG KONG Hong Kong Aportación de la UE Sin datos Dirección 21 Sassoon Road POKFULAM Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos NATIONAL HEALTH RESEARCH INSTITUTES, TAIWAN Taiwán Aportación de la UE Sin datos Dirección 128 Yen-Chiu-Yuan Rd. Sec. 2 TAIPEI CITY Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos LABORATORY OF RESPIRATION DEPT., GENERAL HOSPITAL OF PLA, BEIJING CHINA China Aportación de la UE Sin datos Dirección Fuxing road, 28 BEIJING Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos IC CONSULTANTS LTD Reino Unido Aportación de la UE Sin datos Dirección Sherfield Building, Imperial College London LONDON Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos