Cel The proposal has four key objectives: a) to characterise and quantify the key factors that determine the transmission dynamics of the aetiological agent via epidemiological analysis and clinical studies of material collected from SARS patients, to develop statistical methods to estimate key parameters, and to complete retrospective epidemiological analyses of national or city based databases of the SARS epidemics in Hong Kong, Beijing, and Taiwan that capture the spatial and temporal network structure of mixing between individuals; b) to define ideal structures for case databases to facilitate rapid analysis and interpretation of epidemic trends and the impact of interventions; c) to create a mathematical framework for studying optimal control policies for directly transmitted respiratory tract infectious diseases in both local, country-wide and global contexts, to inform policy makers; d) to develop models for scenario and risk analysis to explore how best to control defined infectious disease epidemics. The proposal builds on past work with collaborators in Hong Kong which facilitated the creation of a structured database for all SARS cases in those regions and Taiwan, and the analysis day by day of the course of the epidemic and the impact of different interventions (Riley et al, Science May 23rd, 2003; Donnelly et al., Lancet, May 7th, 2003). Clinical aspects to be addressed in this proposal include: the typical course of infection in patients of different ages and with various co-morbidities; the infectiousness (level of viral shedding) of patients through time following acquisition of infection; and the distributions of incubation and infectious periods as a function of modifying factors such as age. Epidemiological aspects include the routes of transmission of the virus, and the types of contacts that resulted in transmission. Although much of the research will be focused on SARS, the overall aims include the development of a mathematical... Dziedzina nauki medical and health scienceshealth sciencespublic healthnatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesnatural sciencesmathematicsapplied mathematicsmathematical model Słowa kluczowe Mathematical models contact tracing databases epidemic analysis intervention Program(-y) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) POLICIES-2.2 - Public health issues, including epidemiology contributing to disease prevention and responses to emerging rare and communicable diseases, allergies, procedures for secure blood and organ donations, non-animal test methods Zaproszenie do składania wniosków FP6-2003-SSP-2-SARS Zobacz inne projekty w ramach tego zaproszenia System finansowania STIP - Specific Targeted Innovation Project Koordynator IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Wkład UE Brak danych Adres Imperial College London, South Kensington Campus LONDON Zjednoczone Królestwo Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francja Wkład UE Brak danych Adres 101, rue de Tolbiac PARIS Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITEIT UTRECHT Niderlandy Wkład UE Brak danych Adres Heidelberglaan 8 80125 UTRECHT Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych DEPARTMENT OF COMMUNITY MEDICINE, THE UNIVERSITY OF HONG KONG Hongkong Wkład UE Brak danych Adres 21 Sassoon Road POKFULAM Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych NATIONAL HEALTH RESEARCH INSTITUTES, TAIWAN Tajwan Wkład UE Brak danych Adres 128 Yen-Chiu-Yuan Rd. Sec. 2 TAIPEI CITY Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych LABORATORY OF RESPIRATION DEPT., GENERAL HOSPITAL OF PLA, BEIJING CHINA Chiny Wkład UE Brak danych Adres Fuxing road, 28 BEIJING Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych IC CONSULTANTS LTD Zjednoczone Królestwo Wkład UE Brak danych Adres Sherfield Building, Imperial College London LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych
