Objective
A detailed understanding of the processes responsible for the failure in achieving or in maintaining the normal functional structures of proteins is of crucial importance in the development of strategies to protect or enhance human health. To gain biologic al function, polypeptide chains generally need to fold into specific three- dimensional structures - their native states. Abberrant folding of proteins can lead to a range of other scenarios, including the development of highly organised and intractable ag gregates that are deposited inside or outside cells. Such misfolding events are at the origins of a range of neurological and systemic diseases that increasingly compromise the quality and expectancy of life and the health resources of advanced societies. The focus of this application is the development of novel methods to study the structural slates of proteins that are particularly relevant to understand protein misfolding and aggregation. The species involved range from highly flexible unfolded monomers to soluble oligomers and precursors of fibrillar aggregates. In most of these states, polypeptide chains acquire structures that differ substantially from those of the native proteins that are accessible from conventional approaches of structural biology o r from structural genomics procedures. The major techniques that will be used to define at atomic level the structural characteristics of the range of species relevant to understanding misfolding and aggregation is NMR spectroscopy. In this STREP, a range of complementary NMR approaches will be developed by the various partners for this purpose. These approaches include a variety of NMR techniques and will be coupled with novel computational approaches able to define even the disorganised ensembles characte risitic of some of the most interesting and biologically relevant species. These approaches will then be applied to representative examples of the various types of proteins #
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences physical sciences optics spectroscopy absorption spectroscopy
- natural sciences biological sciences biochemistry biomolecules proteins protein folding
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-I
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
FRANKFURT/MAIN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.