Objective The aims of this proposal are to study how lymphatic vessels grow in health and disease, and to identify and characterize novel candidate genes of lymphangiogenesis important for human disease and possible targets for drug development of lymphatic disorder s. This will be achieved by performing functional lymphangiogenomics. First by using Xenopus laevis tadpoles, a novel model organism to on a large scale and rapid pace study lymphangiogenesis, the function of genes of interest (selected by micro-array profiling) will be studied via genetic manipulation (RNA/DNA over expression and morpholino knockdown).The most promising lymphangiogenic candidates will then be knocked down in the mouse and their role in health and disease will be studied as well as their molecular mechanisms in vitro and the therapeutic potential for treating lymphatic disorders in vivo. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesclinical medicineangiologymedical and health sciencesclinical medicineembryology Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2002-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Address Rijvisschestraat 120 Zwijnaarde Belgium See on map Links Website Opens in new window EU contribution € 0,00
