Obiettivo The aims of this proposal are to study how lymphatic vessels grow in health and disease, and to identify and characterize novel candidate genes of lymphangiogenesis important for human disease and possible targets for drug development of lymphatic disorder s. This will be achieved by performing functional lymphangiogenomics. First by using Xenopus laevis tadpoles, a novel model organism to on a large scale and rapid pace study lymphangiogenesis, the function of genes of interest (selected by micro-array profiling) will be studied via genetic manipulation (RNA/DNA over expression and morpholino knockdown).The most promising lymphangiogenic candidates will then be knocked down in the mouse and their role in health and disease will be studied as well as their molecular mechanisms in vitro and the therapeutic potential for treating lymphatic disorders in vivo. Campo scientifico scienze mediche e della salutemedicina di basefarmacologia e farmaciascoperta di farmaciscienze mediche e della salutescienze della salutemalattie infiammatoriescienze mediche e della salutebiotecnologia medicaingegneria geneticascienze mediche e della salutemedicina clinicaangiologiascienze mediche e della salutemedicina clinicaembriologia Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Invito a presentare proposte FP6-2002-MOBILITY-5 Vedi altri progetti per questo bando Meccanismo di finanziamento EIF - Marie Curie actions-Intra-European Fellowships Coordinatore FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Indirizzo Rijvisschestraat 120 Zwijnaarde Belgio Mostra sulla mappa Collegamenti Sito web Opens in new window Contributo UE Nessun dato
