Objective
In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health scienceshealth sciencesinfectious diseasesmalaria
- medical and health sciencesbasic medicinemedicinal chemistry
- medical and health sciencesclinical medicinepneumologytuberculosis
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Keywords
Call for proposal
FP6-2003-LIFESCIHEALTH-3
See other projects for this call
Funding Scheme
STIP - Specific Targeted Innovation ProjectCoordinator
GIESSEN
Germany