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Oxygen-sensitive enzymes of the mevalonate-independent isoprenoid biosynthesis pathway as targets for new antimalarial and anti-TB drugs

Objective

In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.

Call for proposal

FP6-2003-LIFESCIHEALTH-3
See other projects for this call

Coordinator

JUSTUS LIEBIG UNIVERSITY GIESSEN
Address
Ludwigstrasse 24
Giessen
Germany

Participants (2)

KIADIS B.V.
Netherlands
Address
Zernikepark 6-8
Groningen
GHENT UNIVERSITY
Belgium
Address
Sint-pietersnieuwstraat 25
Gent