Objective In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicinemedicinal chemistrymedical and health sciencesclinical medicinepneumologytuberculosisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords high resolution screening iron-sulphur cluster isoprenoid biosynthesis malaria tuberculosis Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies Call for proposal FP6-2003-LIFESCIHEALTH-3 See other projects for this call Funding Scheme STIP - Specific Targeted Innovation Project Coordinator JUSTUS LIEBIG UNIVERSITY GIESSEN EU contribution No data Address Ludwigstrasse 24 GIESSEN Germany See on map Links Website Opens in new window Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all KIADIS B.V. Netherlands EU contribution No data Address Zernikepark 6-8 GRONINGEN See on map Links Website Opens in new window Total cost No data GHENT UNIVERSITY Belgium EU contribution No data Address Sint-Pietersnieuwstraat 25 GENT See on map Links Website Opens in new window Total cost No data
