Oxygen-sensitive enzymes of the mevalonate-independent isoprenoid biosynthesis pathway as targets for new antimalarial and anti-TB drugs

Información del proyecto

02-SENSITIVE TARGETS

Identificador del acuerdo de subvención: 516017

Proyecto cerrado

Fecha de inicio 1 Enero 2005

Fecha de finalización 31 Diciembre 2006

Financiado con arreglo a

• Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Coste total € 1 349 000,00

Aportación de la UE € 1 000 000,00

Coordinado por

JUSTUS LIEBIG UNIVERSITY GIESSEN
Germany

Objetivo

In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.

Ámbito científico

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › basic medicine › medicinal chemistry
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Palabras clave

• high resolution screening
• iron-sulphur cluster
• isoprenoid biosynthesis
• malaria
• tuberculosis

Programa(s)

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Tema(s)

• LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies

Convocatoria de propuestas

FP6-2003-LIFESCIHEALTH-3
Consulte otros proyectos de esta convocatoria

Régimen de financiación

STIP - Specific Targeted Innovation Project

Coordinador

JUSTUS LIEBIG UNIVERSITY GIESSEN

• Aportación de la UE: Sin datos
• Dirección: Ludwigstrasse 24 ; GIESSEN ; Alemania
• Coste total: Sin datos

Participantes (2)

KIADIS B.V.

Países Bajos

• Aportación de la UE: Sin datos
• Dirección: Zernikepark 6-8 ; GRONINGEN
• Coste total: Sin datos

GHENT UNIVERSITY

Bélgica

• Aportación de la UE: Sin datos
• Dirección: Sint-Pietersnieuwstraat 25 ; GENT
• Coste total: Sin datos