Oxygen-sensitive enzymes of the mevalonate-independent isoprenoid biosynthesis pathway as targets for new antimalarial and anti-TB drugs

Projektinformationen

02-SENSITIVE TARGETS

ID Finanzhilfevereinbarung: 516017

Projekt abgeschlossen

Startdatum 1 Januar 2005

Enddatum 31 Dezember 2006

Finanziert unter

• Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Gesamtkosten € 1 349 000,00

EU-Beitrag € 1 000 000,00

Koordiniert durch

JUSTUS LIEBIG UNIVERSITY GIESSEN
Germany

Ziel

In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• medical and health sciences › health sciences › infectious diseases › malaria
• medical and health sciences › basic medicine › medicinal chemistry
• medical and health sciences › clinical medicine › pneumology › tuberculosis
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Schlüsselbegriffe

• high resolution screening
• iron-sulphur cluster
• isoprenoid biosynthesis
• malaria
• tuberculosis

Programm/Programme

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Thema/Themen

• LIFESCIHEALTH-2.3.0 - Developing new promising candidate vaccines and therapies

Aufforderung zur Vorschlagseinreichung

FP6-2003-LIFESCIHEALTH-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

STIP - Specific Targeted Innovation Project

Koordinator

JUSTUS LIEBIG UNIVERSITY GIESSEN

• EU-Beitrag: Keine Daten
• Adresse: Ludwigstrasse 24 ; GIESSEN ; Deutschland
• Gesamtkosten: Keine Daten

Beteiligte (2)

KIADIS B.V.

Niederlande

• EU-Beitrag: Keine Daten
• Adresse: Zernikepark 6-8 ; GRONINGEN
• Gesamtkosten: Keine Daten

GHENT UNIVERSITY

Belgien

• EU-Beitrag: Keine Daten
• Adresse: Sint-Pietersnieuwstraat 25 ; GENT
• Gesamtkosten: Keine Daten