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From Immune Responses in Rare Autoimmune Diseases to novel Therapeutic Intervention Strategies-a personalized Medicine approach

Objective

The European research network, AUTOROME, represents Centers of Excellence in Europe where recent technologies in studying the pathophysiology of humoral and cellular autoimmunity are combined and applied to improve in a personalized manner diagnosis and treatment of rare human autoimmune diseases such as e.g. sclerodermie, systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic vasculitis as well as autoimmune lymphoproliferative syndrome (ALPS). Rare Autoimmune diseases are associated with substantial morbidity and even accelerated mortality in affected persons (children and elderly) Combined efforts will be undertaken to explore the disease potential of pathogenic autoantibodies that might be involved in determining disease-related organ specificities. The AUTOROME project (www.autorome.com) is divided into 4 workpackages. These are Autoantigen and Autoantibody Mapping (WP1), Isotype-specific peptides (WP2), Dysfunction of the Immune System (WP3), Basic Developmental Mechanisms of the Immune System (WP4), By characterizing epitope-paratope / antigen-antibody interactions diagnostic tools will be generated to study in a personalized manner the pathogenicity of rare autoimmune diseases due to individual autoantibody signatures on a patient to patient basis. Deliverables (D1-D12) include diagnostic kits as well as autoantigen and antibody chips to be developed and validated in clinical settings. By deciphering the B- and T-cell repertoire displayed in autoimmune diseases, novel cellular targets are expected to become available for therapeutic intervention strategies using idiotype-specific peptides as well as therapeutic antibody and siRNA approaches. The feasibility of these approaches will be preclinically assessed in animal models - a prerequisite for conducting clinical trials.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

STREP - Specific Targeted Research Project
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Coordinator

UNIVERSITY OF ROSTOCK
Address
Universitätsplatz 1
Rostock
Germany

Participants (11)

4-ANTIBODY AG
Switzerland
Address
Klingelbergstrasse 50
Basel
BIOTECHNOLOGIE INSTITUT THURGAU
Switzerland
Address
Konstanzerstrasse 19
Tägerwillen
GERMAN ARTHRITIS RESEARCH CENTRE BERLIN DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN
Germany
Address
Schumannstr. 20/21
Berlin
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL
France
Address
101 Rue De Tolbiac
Paris
INSTITUT PASTEUR
France
Address
28 Rue Du Dr. Roux
Paris
ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland
Address
123 St. Stephens Green
Dublin 2
SHEBA MEDICAL CENTER, TEL-HASHOMER
Israel
Address
Tel Hashomer
Ramat Gan
UNIVERSITÄTSKLINIK FREIBURG
Germany
Address
Hugstetter Str. 55
Freiburg
VAECGENE BIOTECH GMBH
Germany
Address
Marchionistr. 25
Munich
VU UNIVERSITY MEDICAL CENTER
Netherlands
Address
Van Der Boechorststraat 7
Amsterdam
ZEPTOSENS AG
Switzerland
Address
Benkenstr. 254
Witterswil