Objective Cell-based screenings are today a necessary tool for all types of clinical development and/or market approval of new drugs and chemicals. The major change in the last decade is a shift towards more physiologically relevant yet complex and sensitive cell models, like stem cells, and more recently, the shift to human induced pluripotent cells. Stem-cell technology has the potential to revolutionize drug discovery, making models available for primary screens, secondary pharmacology, safety pharmacology, metabolic profiling and toxicity evaluation. The overall aim of DropTech is the development of automated handling processes for stem cells with integrated readout methods, required for the use of stem cells in high-throughput assays such as the embryonic stem cell test (EST). DropTech will result on the one hand in a fully automated screening platform, usable by the industrial partners for reproducible and standardized high-throughput screening services and aggregate production. On the other hand a system that is directly exploitable for industrialization and marketing will be available to perform reliable and fast at least semi-automated screening approaches for customers. Therefore, the complete workflow of the EST, including stem cell expansion, embryoid body formation in hanging drops and transfer to 2D conditions will be automated using robotic and microfluidics systems. This will enable standardized, fast and efficient embryotoxicity screenings reducing the need for animal tests. DropTech will enable testing in a small- and medium-scaled budget accessible for SMEs and academia in the field of biotech and biomedicine. The DropTech platform will have therefore a significant impact on the development of new medication and therapies and will enable personalized medicine approaches as well as - in future - regenerative medicine. DropTech facilitate the use of cell models with highest biological relevance (human pluripotent stem cells) in their native conformation. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health scienceshealth sciencespersonalized medicine Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.0-1 - Boosting the translation of health research projects' results into innovative applications for health Call for proposal FP7-HEALTH-2013-INNOVATION-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Address Hansastrasse 27c 80686 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andrea Zeumann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 2 015 949,00 Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all European ScreeningPort GmbH Participation ended Germany EU contribution € 943 135,00 Address Schnackenburgallee 22525 Hamburg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mira Grättinger (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ROSLIN CELLAB LIMITED United Kingdom EU contribution € 816 139,00 Address Wallace building roslin biocentre EH25 9PP Roslin midlothian See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Malcolm Bateman (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ARTTIC France EU contribution € 276 096,00 Address 39 rue des mathurins 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Annette Ringwald (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
