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bioREACtor for stem cell tHerapy

Objective

The REACH-project is a direct result of the FP7 StemExpand project, which aimed at the expansion and engraftment of hematopoietic and mesenchymal stem cells (MSC) for clinical use. The results of these research activities show that a novel, closed and controlled bioreactor can be developed to grow clinically relevant numbers (>400 million) of MSCs. XPand Biotechnology BV(NL) [bioreactor development, technology valorization], Aber Instruments ltd (UK)[biomass sensor] and PreSens Precision Sensing GmbH (GE) [DO, pH sensor] are three SMEs that have teamed up to develop this novel bioreactor system to a pre-commercial scale. The overall aim of the REACH project is to further develop and engineer the bioreactor (incl. valorization, testing and technical and biological validation) to a closed-system sensor-controlled bioreactor with sampling possibilities that allows for GMP-grade MSC production outside a cleanroom. The system will contain a disposable bioreactor bag with unique miniaturized disposable sensors. The DO and pH sensors use optical chemical methods capable of high frequency sampling, this ensures an enhanced stability of the expansion process. Using an expandable bioreactor the volume can be increased during cell culture, without the need for passaging of the cells. Because of this feature the system can be truly closed, without the limitations of a fixed culture substrate area. Leiden University Medical Center (NL) will validate the system and the products in a clinical setting by comparing bioreactor-expanded MSCs with GMP grade MSCs produced by established protocols in the LUMC. Successful development of this bioreactor system will be beneficial for the participating SMEs as well as the medical sector which will be able to develop cell therapies in a faster, cheaper and more efficient way. Collectively, the partners in REACH will develop an exploitation and business plan for the successful valorization of the research done in the FP7 StemExpand project.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /social sciences/economics and business
  • /engineering and technology/environmental biotechnology/bioremediation/bioreactor
  • /agricultural sciences/agricultural biotechnology/biomass

Call for proposal

FP7-HEALTH-2013-INNOVATION-2
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH ZIEKENHUIS LEIDEN
Address
Albinusdreef 2
2333 ZA Leiden
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 123 915,20
Administrative Contact
Brigitte Wieles (Dr.)

Participants (3)

KUROS BIOSCIENCES BV
Netherlands
EU contribution
€ 2 365 211,69
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Joost De Bruijn (Prof.)
ABER INSTRUMENTS LIMITED
United Kingdom
EU contribution
€ 478 359,73
Address
Science Park Unit 5 Cefn Llan
SY23 3AH Abersystwyth
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Matthew Lee (Mr.)
PRESENS PRECISION SENSING GMBH
Germany
EU contribution
€ 1 044 640,40
Address
Am Biopark 11
93053 Regensburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gernot John (Dr.)