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Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe

Objetivo

Background Ixodes ricinus transmits bacterial, protozoal and viral pathogens that cause Lyme borreliosis, babesiosis and tick-borne encephalitis respectively and exceedingly affect Central and Eastern Europe (CEE). During feeding, ticks introduce salivary proteins in the skin that interfere with host defense mechanisms. However, in animals repeated tick infestations as well as vaccination against selected tick proteins can lead to decreased pathogen transmission by inhibiting tick feeding - known as ‘tick immunity’ - or by neutralizing tick proteins that facilitate the transmission of tick-borne pathogens (TBPs). Also humans with hypersensitivity to tick-bites have a lower risk of contracting tick-borne diseases (TBDs). Therefore, anti-tick vaccines encompass an innovative strategy to prevent TBDs in humans, or animals and wildlife to indirectly reduce the risk of contracting TBDs for humans.

Overall Objective To identify and characterize tick proteins involved in ‘tick immunity’ and TBP transmission and to use this knowledge to develop anti-tick vaccines to prevent multiple human TBDs.

Methods Using state of the art proteomic and transcriptomic approaches we will identify and characterize novel tick salivary gland proteins, which will be subsequently assessed as anti-tick vaccines to protect against LB, babesiosis and TBE in animal models. In addition, through an integrated and multidisciplinary approach involving CEE public health institutes, health organizations and industrial companies we will examine how to develop anti-tick vaccines and implement these in public health systems.

Impact ANTIDotE will deliver 1) essential knowledge on the biological mechanisms involved in the pathogenesis of TBDs, 2) proof of concept of an anti-tick vaccine protecting against multiple human TBPs and 3) plans for exploitation and implementation of anti-tick vaccines, significantly contributing to downscaling the severe medical and economic burden that TBDs have on societies.

Convocatoria de propuestas

FP7-HEALTH-2013-INNOVATION-1
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Coordinador

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Dirección
Meibergdreef 15
1105AZ Amsterdam
Países Bajos
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 988 320
Contacto administrativo
Frank Groen (Mr.)

Participantes (7)

VIROLOGICKY USTAV SLOVENSKEJ AKADEMIE VIED

La participación finalizó

Eslovaquia
Dirección
Dubravska Cesta 9
84505 Bratislava
Tipo de actividad
Research Organisations
Contacto administrativo
Hana Krasoňová (Ms.)
Biologicke centrum AV CR, v. v. i.
Chequia
Aportación de la UE
€ 565 900
Dirección
Branisovska 31
370 05 Ceske Budejovice
Tipo de actividad
Research Organisations
Contacto administrativo
Zdenka Grufikova (Ms.)
FREIE UNIVERSITAET BERLIN
Alemania
Aportación de la UE
€ 466 100
Dirección
Kaiserswerther Strasse 16-18
14195 Berlin
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Annegret Körner (Ms.)
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
España
Aportación de la UE
€ 373 400
Dirección
Parque Tecnologico Edificio 801 A
48160 Derio Vizcaya
Tipo de actividad
Research Organisations
Contacto administrativo
Alfonso Egaña (Mr.)
GENXPRO GMBH
Alemania
Aportación de la UE
€ 208 700
Dirección
Altenhofter Allee 3
60438 Frankfurt
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Cornelia Lenhart (Ms.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Países Bajos
Aportación de la UE
€ 141 445
Dirección
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Tipo de actividad
Research Organisations
Contacto administrativo
Marjon Hartwigsen (Mrs.)
BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED
Eslovaquia
Aportación de la UE
€ 255 920
Dirección
Dubravska Cesta 9
845 05 Bratislava
Tipo de actividad
Research Organisations
Contacto administrativo
Hana Krasoňová (Ms.)