Objective More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medical treatment has been shown to be effective and the economic, social and personal burden of HFPEF is enormous; this disease constitutes one of the most pressing unmet clinical needs. A cardinal feature of HFPEF is exercise intolerance. The pathophysiology of exercise intolerance in HFPEF depends on multiple factors in heart, endothelium and skeletal muscles. From a pathophysiological point of view, exercise could by far outweigh any pharmacological intervention in this heterogeneous syndrome, since lifestyle dependent risk factor, physical inactivity, and physical deconditioning underlay and contribute to HFPEF. OptimEx will focus on the cardiovascular effects of exercise training as primary and secondary prevention of HFPEF. We will combine in vivo and in vitro studies in man and rats in serial experiments that will advance our understanding of fundamental cellular and molecular mechanisms underpinning dose-dependent exercise-induced changes in the heart, blood vessels and skeletal muscles. This research is aimed to tackle one of the major health problems the developed world faces with its ageing societies and increasing prevalence of the HFPEF and will support sustainable health systems in EU member states through improvements in the clinical management of a common and disabling disease. The project is therefore highly relevant to improve the health of European citizens and important to promote healthy ageing and preventing disease. Fields of science medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesclinical medicinecardiologycardiovascular diseases Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.4.2-3 - Optimising lifestyle interactions in the prevention and treatment of cardiovascular disease across the lifespan Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Address Hogskoleringen 1 7491 Trondheim Norway See on map Activity type Higher or Secondary Education Establishments projects.administrative_contact Ulrik Wisløff (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 102 075,20 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET LEIPZIG Germany EU contribution € 527 460,00 Address Ritterstrasse 26 04109 Leipzig See on map Activity type Higher or Secondary Education Establishments projects.administrative_contact Volker Adams (Dr.) Links Contact the organisation Opens in new window Website Opens in new window KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany EU contribution € 536 600,00 Address Ismaninger strasse 22 81675 Muenchen See on map Activity type Higher or Secondary Education Establishments projects.administrative_contact Renate Rädlein (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAIR ZIEKENHUIS ANTWERPEN Belgium EU contribution € 353 875,60 Address Drie eikenstraat 655 2650 Edegem See on map Activity type Research Organisations projects.administrative_contact Viviane Conraads (Prof.) Links Contact the organisation Opens in new window Website Opens in new window MEDIZINISCHE UNIVERSITAT GRAZ Participation ended Austria EU contribution € 1 919,74 Address Neue stiftingtalstrasse 6 8010 Graz See on map Activity type Higher or Secondary Education Establishments projects.administrative_contact Carolin Auer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Vitaphone GmbH Germany EU contribution € 128 407,50 Address Markircher strasse 22 68229 Mannheim See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) projects.administrative_contact Walter Schmid (Mr.) Links Contact the organisation Opens in new window Website Opens in new window CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 349 657,66 Address Chariteplatz 1 10117 Berlin See on map Activity type Higher or Secondary Education Establishments projects.administrative_contact Martina Eickmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window
