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IMAging GEnetics for MENtal Disorders

Objective

Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research literature exists, few neuroimaging applications have reached clinical practice in psychiatry. A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. Instead, recent results show that mental disorders are best understood as quantitative alterations in neural systems relevant across traditional diagnostic boundaries that reflect individual, genetic and environmental risk factors. In the IMAGEMEND consortium, we aim to discover these systems to identify the patient characteristics most relevant for treatment, derive biomarkers and decision rules from this systems-level dimensional account, and systematically validate biomarker panels in patient, high-risk and epidemiological samples to produce automated imaging-based diagnostic and predictive tests tailored for wide distribution throughout Europe in standard clinical settings. Focusing on schizophrenia, bipolar disorder and attention deficit-hyperactivity disorder, we have assembled Europe’s largest dataset combining neuroimaging, genetic, environmental, cognitive and clinical information on approximately 13000 participants, and have recruited international replication datasets of more than 30000 people. This unique resource will be processed using a new generation of multivariate statistical analysis to optimize existing imaging technology for the benefit of patients. We will also develop new imaging technology to enable the direct imaging-based therapeutic modification of neural circuits through rapid real-time MRI. Our deliverables will promote personalized treatment through more accurate patient stratification, allow diagnoses at the pre-symptomatic stage for early intervention and prevention, and improve prediction of treatment response and disease progression.

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Address
Square J 5
68159 Mannheim
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 718 160
Administrative Contact
Andreas Meyer-Lindenberg (Prof.)

Participants (13)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 416 626
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 420 000
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andreas Papassotiropoulos (Prof.)
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 420 000
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Delfina Maria Misuraca (Mrs.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 420 000
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
LIFE AND BRAIN GMBH
Germany
EU contribution
€ 720 000
Address
Venusberg-campus 1
53127 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markus Noethen (Prof.)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 420 000
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans Mossin (Mr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 420 000
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marten Van Langen (Mr.)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 480 000
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frosti Jonsson (Mr.)
BRAIN INNOVATION BV
Netherlands
EU contribution
€ 780 000
Address
Oxfordlaan 55
6229 EV Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Claudia Goebel (Mrs.)
Concentris Research Management GmbH
Germany
EU contribution
€ 300 000
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Dr.)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 91 840
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Hasenpusch (Ms.)
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH

Participation ended

Australia
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
Administrative Contact
Lee Casey (Ms.)
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
EU contribution
€ 393 374
Address
One Gustave L Levy Place Box 1075
10029 6574 New York
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Allison Gottlieb (Mr.)