Skip to main content

IMAging GEnetics for MENtal Disorders

Objectif

Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research literature exists, few neuroimaging applications have reached clinical practice in psychiatry. A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. Instead, recent results show that mental disorders are best understood as quantitative alterations in neural systems relevant across traditional diagnostic boundaries that reflect individual, genetic and environmental risk factors. In the IMAGEMEND consortium, we aim to discover these systems to identify the patient characteristics most relevant for treatment, derive biomarkers and decision rules from this systems-level dimensional account, and systematically validate biomarker panels in patient, high-risk and epidemiological samples to produce automated imaging-based diagnostic and predictive tests tailored for wide distribution throughout Europe in standard clinical settings. Focusing on schizophrenia, bipolar disorder and attention deficit-hyperactivity disorder, we have assembled Europe’s largest dataset combining neuroimaging, genetic, environmental, cognitive and clinical information on approximately 13000 participants, and have recruited international replication datasets of more than 30000 people. This unique resource will be processed using a new generation of multivariate statistical analysis to optimize existing imaging technology for the benefit of patients. We will also develop new imaging technology to enable the direct imaging-based therapeutic modification of neural circuits through rapid real-time MRI. Our deliverables will promote personalized treatment through more accurate patient stratification, allow diagnoses at the pre-symptomatic stage for early intervention and prevention, and improve prediction of treatment response and disease progression.

Appel à propositions

FP7-HEALTH-2013-INNOVATION-1
Voir d’autres projets de cet appel

Coordinateur

ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT
Adresse
Square J 5
68159 Mannheim
Allemagne
Type d’activité
Higher or Secondary Education Establishments
Contribution de l’UE
€ 718 160
Contact administratif
Andreas Meyer-Lindenberg (Prof.)

Participants (13)

KING'S COLLEGE LONDON
United Kingdom
Contribution de l’UE
€ 416 626
Adresse
Strand
WC2R 2LS London
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Paul Labbett (Mr.)
UNIVERSITAT BASEL
Suisse
Contribution de l’UE
€ 420 000
Adresse
Petersplatz 1
4051 Basel
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Andreas Papassotiropoulos (Prof.)
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italie
Contribution de l’UE
€ 420 000
Adresse
Piazza Umberto I 1
70121 Bari
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Delfina Maria Misuraca (Mrs.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
Contribution de l’UE
€ 420 000
Adresse
Old College, South Bridge
EH8 9YL Edinburgh
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Angela Noble (Ms.)
LIFE AND BRAIN GMBH
Allemagne
Contribution de l’UE
€ 720 000
Adresse
Venusberg-campus 1
53127 Bonn
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Markus Noethen (Prof.)
UNIVERSITETET I OSLO
Norvège
Contribution de l’UE
€ 420 000
Adresse
Problemveien 5-7
0313 Oslo
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Hans Mossin (Mr.)
STICHTING RADBOUD UNIVERSITEIT
Pays-Bas
Contribution de l’UE
€ 420 000
Adresse
Houtlaan 4
6525 XZ Nijmegen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Marten Van Langen (Mr.)
ISLENSK ERFDAGREINING EHF
Islande
Contribution de l’UE
€ 480 000
Adresse
Sturlugotu 8
101 Reykjavik
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Frosti Jonsson (Mr.)
BRAIN INNOVATION BV
Pays-Bas
Contribution de l’UE
€ 780 000
Adresse
Oxfordlaan 55
6229 EV Maastricht
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Claudia Goebel (Mrs.)
Concentris Research Management GmbH
Allemagne
Contribution de l’UE
€ 300 000
Adresse
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Ameli Schwalber (Dr.)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Allemagne
Contribution de l’UE
€ 91 840
Adresse
Regina Pacis Weg 3
53113 Bonn
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Daniela Hasenpusch (Ms.)
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH

Participation terminée

Australie
Adresse
Herston Road, 300
QLD 4006 Herston
Type d’activité
Research Organisations
Contact administratif
Lee Casey (Ms.)
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
États-Unis
Contribution de l’UE
€ 393 374
Adresse
One Gustave L Levy Place Box 1075
10029 6574 New York
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Allison Gottlieb (Mr.)